METASTATIC COLORECTAL CARCINOMA

This study is for people with advanced gastrointestinal cancers that are getting worse despite immunotherapy. It tests whether giving focused radiation to one tumor can help the immune system attack other tumors throughout the body. About 28 participants will receive radiation wh…

This study tests whether adding a special chemotherapy pump that delivers drugs directly to the liver (hepatic arterial infusion, or HAI) to standard chemotherapy helps people with colorectal cancer that has spread to the liver live longer. About 408 adults whose liver tumors can…

This early-phase trial is testing a procedure called PIPAC, which turns liquid chemotherapy into a fine mist and sprays it directly into the abdomen during a keyhole surgery. It is for people with ovarian, uterine, appendix, colorectal, or stomach cancer that has spread to the li…

This early-stage trial tests the safety and best dose of a new drug (ZEN003694) combined with a standard chemotherapy (capecitabine) in adults with solid tumors that have spread or cannot be removed by surgery and have stopped responding to prior treatments. The goal is to find a…

This early-stage trial tests a new radioactive drug, [225Ac]-FPI-2068, in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and see how the drug spreads in the body. About 70 people with cancers like lung, colon, …

This early-phase study is testing whether giving two standard chemotherapy drugs (5FU and oxaliplatin) directly into the abdomen is safe and effective for people with colorectal cancer that has spread only to the belly lining. About 24 adults with this condition will receive the …

This study tests whether giving the cancer drug nivolumab as a shot at home is as safe and effective as getting it in a clinic. About 50 adults with various cancers will try both settings to see which they prefer and how it affects their quality of life. The goal is to reduce the…

This study tests whether adding cryoablation (freezing cancer cells) to standard radiation therapy provides better pain relief for people with cancer that has spread to the bones. About 40 adults with certain advanced cancers (like prostate, kidney, or colorectal) will be enrolle…

This study collects tissue samples from people with various advanced or early-stage cancers to train a diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 participant…

This study is testing a special type of MRI scan called IVIM DWI to see if it can better measure how colorectal cancer liver tumors respond to chemotherapy. About 70 adults with liver metastases that have not been treated yet will get the scan before and after chemo. The goal is …

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to see how these vessels work, which could help decide if a patient's tumor is likely to respond to certain treatments.…