MELANOMA STAGE IV
Clinical trials for MELANOMA STAGE IV explained in plain language.
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New drug ST101 tested in patients with advanced cancers
Disease control OngoingThis study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1, PHASE2 • Sponsor: Sapience Therapeutics • Aim: Disease control
Last updated May 26, 2026 05:50 UTC
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New drug combo aims to unleash immune system against advanced melanoma
Disease control OngoingThis early-stage study tests a new drug, SX-682, combined with the immunotherapy pembrolizumab in people with advanced melanoma. The goal is to see if SX-682 can block cancer's ability to hide from the immune system, making the immunotherapy more effective. About 77 participants …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1 • Sponsor: Syntrix Biosystems, Inc. • Aim: Disease control
Last updated May 26, 2026 05:44 UTC
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New drug combo shows promise in shrinking advanced melanoma before surgery
Disease control OngoingThis study tests whether a combination of two immunotherapy drugs (dostarlimab and cobolimab) works better than one drug alone (dostarlimab) in shrinking advanced melanoma before surgery. About 48 adults with stage III or limited stage IV melanoma that can be removed will receive…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Diwakar Davar • Aim: Disease control
Last updated May 26, 2026 04:37 UTC
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New vaccine combo shows promise in advanced skin cancer trial
Disease control OngoingThis study tests two experimental cancer vaccines, SCIB1 and iSCIB1+, given alongside standard immunotherapy drugs (nivolumab with ipilimumab or pembrolizumab) for people with advanced melanoma that cannot be removed by surgery. The goal is to see if adding the vaccines is safe a…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Scancell Ltd • Aim: Disease control
Last updated May 20, 2026 11:54 UTC
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Spinal injection of immunotherapy shows promise for hard-to-treat brain metastasis
Disease control OngoingThis early-phase study tests whether injecting two immunotherapy drugs directly into the spinal fluid, along with standard IV doses, is safe and can shrink tumors in the brain and spinal cord lining. It includes 26 adults with advanced lung cancer or melanoma that has spread to t…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1 • Sponsor: University of Zurich • Aim: Disease control
Last updated May 20, 2026 11:54 UTC
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New combo shows promise against tough skin cancer
Disease control OngoingThis study tests a new drug, EVX-01, combined with the standard immunotherapy pembrolizumab in 17 adults with advanced melanoma that cannot be removed by surgery. The goal is to see if the combination shrinks tumors better than pembrolizumab alone. Participants have not received …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Evaxion Biotech A/S • Aim: Disease control
Last updated May 18, 2026 12:03 UTC
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New hope for skin cancer patients suffering from severe gut side effects of immunotherapy
Symptom relief OngoingThis study looks at whether infliximab can treat colitis (inflammation of the colon) caused by immunotherapy drugs in people with advanced skin cancer. About 42 participants will receive either infliximab or steroids to see which works better at stopping symptoms without needing …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated May 12, 2026 13:42 UTC
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Melanoma Survivors' immunotherapy side effects under the microscope
Knowledge-focused OngoingThis study looks at side effects and symptom burden in people with melanoma who are receiving immunotherapy after surgery. Researchers will track side effects, quality of life, depression, and fatigue over 24 months. They also want to see if certain blood markers are linked to th…
Matched conditions: MELANOMA STAGE IV
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 26, 2026 05:48 UTC