MELANOMA STAGE IV
Clinical trials for MELANOMA STAGE IV explained in plain language.
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New drug aims to unmask melanoma to the immune system
Disease control OngoingThis early-stage trial tests a new oral drug, SX-682, combined with the immunotherapy pembrolizumab in people with advanced melanoma. The goal is to see if SX-682 can stop cancer from hiding from the immune system, making the immunotherapy work better. About 77 participants will …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1 • Sponsor: Syntrix Biosystems, Inc. • Aim: Disease control
Last updated Jun 23, 2026 19:17 UTC
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New hope for advanced cancers? ST101 drug enters human trials
Disease control OngoingThis study tests an experimental drug called ST101 in people with advanced solid tumors, including glioblastoma, melanoma, breast, and prostate cancers that have spread or cannot be removed by surgery. The trial has two parts: first, finding a safe dose, and second, seeing if the…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1, PHASE2 • Sponsor: Sapience Therapeutics • Aim: Disease control
Last updated Jun 23, 2026 11:59 UTC
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Can a rheumatoid arthritis drug tame immunotherapy side effects?
Disease control OngoingThis study tests whether infliximab, a drug used for inflammatory conditions, can treat colitis (colon inflammation) caused by immune checkpoint inhibitors in people with stage III or IV skin cancer. About 42 participants will receive either infliximab or steroids, and researcher…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 23, 2026 11:56 UTC
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New combo therapy aims to shrink melanoma before surgery
Disease control OngoingThis study tests whether giving one or two immunotherapy drugs before surgery can shrink advanced melanoma (stage III or IV) that can be removed. About 48 adults with operable melanoma will receive either a single drug (dostarlimab) or a combination (dostarlimab plus cobolimab) b…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Diwakar Davar • Aim: Disease control
Last updated Jun 22, 2026 12:09 UTC
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New combo shows promise against tough skin cancer
Disease control OngoingThis study tests a new drug, EVX-01, combined with the standard immunotherapy pembrolizumab in 17 adults with advanced melanoma that cannot be removed by surgery. The goal is to see if adding EVX-01 improves tumor shrinkage compared to historical data with pembrolizumab alone. Pa…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Evaxion Biotech A/S • Aim: Disease control
Last updated Jun 17, 2026 12:05 UTC
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New hope for patients with rare brain lining cancer spread
Disease control OngoingThis early-phase study tests a new way to give immunotherapy drugs (nivolumab and ipilimumab) for patients with lung cancer or melanoma that has spread to the lining of the brain and spinal cord (leptomeningeal metastases). The drugs are given both directly into the spinal fluid …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1 • Sponsor: University of Zurich • Aim: Disease control
Last updated Jun 16, 2026 12:49 UTC
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New vaccine combo shows promise in advanced skin cancer trial
Disease control OngoingThis study tests two experimental cancer vaccines, SCIB1 and iSCIB1+, given alongside standard immunotherapy drugs (nivolumab with ipilimumab or pembrolizumab) for people with advanced melanoma that cannot be removed by surgery. The goal is to see if adding the vaccines is safe a…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Scancell Ltd • Aim: Disease control
Last updated Jun 15, 2026 19:09 UTC
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Melanoma survivors: how does immunotherapy affect your daily life?
Knowledge-focused OngoingThis study looks at side effects and overall well-being in people who have had melanoma and are now getting immunotherapy to prevent the cancer from coming back. Researchers will track side effects and ask participants about their quality of life, depression, and fatigue for up t…
Matched conditions: MELANOMA STAGE IV
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 03, 2026 12:08 UTC