MELANOMA STAGE IV
Clinical trials for MELANOMA STAGE IV explained in plain language.
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New drug ST101 shows promise in early trial for tough cancers
Disease control OngoingThis study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1, PHASE2 • Sponsor: Sapience Therapeutics • Aim: Disease control
Last updated Apr 30, 2026 15:52 UTC
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Experimental vaccines aim to boost immune attack on advanced skin cancer
Disease control OngoingThis study tests two experimental cancer vaccines, SCIB1 and iSCIB1+, in people with advanced melanoma that cannot be removed by surgery. Participants receive these vaccines alongside standard immunotherapy drugs (nivolumab with ipilimumab, or pembrolizumab). The goal is to see i…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Scancell Ltd • Aim: Disease control
Last updated Apr 30, 2026 15:51 UTC
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New combo therapy shows promise for advanced melanoma
Disease control OngoingThis study tests two immunotherapy drugs, dostarlimab alone or combined with cobolimab, in people with stage III or IV melanoma that can be surgically removed. The goal is to see if these treatments shrink tumors before surgery. About 48 adults will take part. The study is active…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Diwakar Davar • Aim: Disease control
Last updated Apr 30, 2026 15:50 UTC
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Spinal injection combo shows promise for Tough-to-Treat brain metastases
Disease control OngoingThis early-phase study tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) directly into the spinal fluid, along with the same drugs through an IV, is safe and effective for people with lung cancer or melanoma that has spread to the lining of the brain. The tr…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1 • Sponsor: University of Zurich • Aim: Disease control
Last updated Apr 30, 2026 15:50 UTC
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New hope for skin cancer patients suffering from severe gut side effects of immunotherapy
Disease control OngoingThis study tests if the drug infliximab can treat severe colitis (gut inflammation) caused by immunotherapy in people with advanced skin cancer. About 42 participants will receive either infliximab or steroids to see which works better at stopping symptoms without needing long-te…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Apr 30, 2026 15:49 UTC