MELANOMA STAGE III
Clinical trials for MELANOMA STAGE III explained in plain language.
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New scan may predict if immunotherapy works before melanoma surgery
Disease control OngoingThis study tests giving two immunotherapy drugs (nivolumab and ipilimumab) before surgery to people with stage III melanoma. The goal is to shrink or kill the tumor and prevent the cancer from coming back. The study also uses an experimental PET scan to see if it can show how wel…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated May 26, 2026 07:43 UTC
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New drug combo aims to unleash immune system against advanced melanoma
Disease control OngoingThis early-stage study tests a new drug, SX-682, combined with the immunotherapy pembrolizumab in people with advanced melanoma. The goal is to see if SX-682 can block cancer's ability to hide from the immune system, making the immunotherapy more effective. About 77 participants …
Matched conditions: MELANOMA STAGE III
Phase: PHASE1 • Sponsor: Syntrix Biosystems, Inc. • Aim: Disease control
Last updated May 26, 2026 07:35 UTC
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New drug combo shows promise in shrinking advanced melanoma before surgery
Disease control OngoingThis study tests whether a combination of two immunotherapy drugs (dostarlimab and cobolimab) works better than one drug alone (dostarlimab) in shrinking advanced melanoma before surgery. About 48 adults with stage III or limited stage IV melanoma that can be removed will receive…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: Diwakar Davar • Aim: Disease control
Last updated May 26, 2026 07:26 UTC
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New vaccine combo shows promise in advanced skin cancer trial
Disease control OngoingThis study tests two experimental cancer vaccines, SCIB1 and iSCIB1+, given alongside standard immunotherapy drugs (nivolumab with ipilimumab or pembrolizumab) for people with advanced melanoma that cannot be removed by surgery. The goal is to see if adding the vaccines is safe a…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: Scancell Ltd • Aim: Disease control
Last updated May 20, 2026 11:54 UTC
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Personalized immunotherapy after melanoma surgery shows promise in preventing return
Disease control OngoingThis study tests whether giving immunotherapy drugs (nivolumab alone or with ipilimumab) after melanoma surgery can prevent the cancer from coming back. The choice of treatment depends on how the tumor responds to a single dose of nivolumab before surgery. About 67 adults with st…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated May 19, 2026 12:01 UTC
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New biosimilar aims to match keytruda in melanoma fight
Disease control OngoingThis study compares FYB206, a biosimilar (a very similar copy) of the cancer drug Keytruda, to the original Keytruda in 96 adults with stage IIB/IIC or III melanoma that has been completely removed by surgery. The goal is to see if FYB206 stays in the body the same way as Keytrud…
Matched conditions: MELANOMA STAGE III
Phase: PHASE1 • Sponsor: Formycon AG • Aim: Disease control
Last updated May 11, 2026 20:52 UTC
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New drug combo shows promise in shrinking melanoma before surgery
Disease control OngoingThis study tests whether giving two drugs, pembrolizumab and lenvatinib, before surgery can help shrink tumors in people with stage III melanoma that can be removed. About 21 adults with resectable stage III melanoma will receive the drugs for 6 weeks, then have surgery to remove…
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: Melanoma Institute Australia • Aim: Disease control
Last updated May 07, 2026 18:41 UTC
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New hope for skin cancer patients suffering from severe gut side effects of immunotherapy
Symptom relief OngoingThis study looks at whether infliximab can treat colitis (inflammation of the colon) caused by immunotherapy drugs in people with advanced skin cancer. About 42 participants will receive either infliximab or steroids to see which works better at stopping symptoms without needing …
Matched conditions: MELANOMA STAGE III
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated May 12, 2026 13:42 UTC