MECHANICAL VENTILATION COMPLICATION

This study tests whether using a special lung-monitoring device (EIT) to set the ventilator during surgery can reduce lung complications like pneumonia or respiratory failure in people having laparoscopic gastric sleeve surgery. About 118 obese adults will be randomly assigned to…

This study looks at whether a drug called remazolam besylate is as good as or better than another sedative (dexmedetomidine) for keeping critically ill patients calm and comfortable while they are on a breathing machine after non-cardiac surgery. About 306 adults aged 18-64 who n…

This study looks at 36 ICU patients with breathing failure who are on a ventilator. Researchers want to see if a new measure called the Pressure-Muscle Index (PMI) can help doctors set the ventilator to give just the right amount of support, avoiding too much help that can weaken…

This study tests a new ultrasound technique to measure how the lungs move and stretch in patients on breathing machines in the intensive care unit. Researchers will collect data from 10 adults with stiff lungs to see if this tool can help detect early signs of lung injury. The go…

This study tests whether a smartphone app called VentilO can help doctors set breathing machines better for patients just after heart surgery. About 76 adults will be randomly assigned to have their ventilator settings chosen by the app or by their doctor. The goal is to see if t…

This study looks at 120 women having laparoscopic gynecologic surgery (including for cancer) to compare two ways of using the breathing machine: volume-controlled and pressure-controlled ventilation. The goal is to see which method better protects lung function and brain oxygen l…

This study looks at whether the heart's pumping ability affects how well ICU patients can breathe on their own after a breathing tube. It involves 250 adults who have been on a ventilator for more than 48 hours and are ready for a breathing test. Researchers will use ultrasound t…

This study looks at whether adjusting the settings on a mechanical cough-assist device (MI-E) can remove more mucus from the lungs of critically ill patients on breathing machines. About 26 adults who have been on a ventilator for more than 48 hours will take part. Researchers wi…

This study looks at how often pain occurs in intensive care patients who are on breathing machines. Researchers will check pain levels using special scales and see if pain is linked to longer time on the ventilator or higher death rates. The goal is to better understand and manag…

This study looks at whether giving ICU staff real-time feedback and having a dedicated nurse facilitator can increase the use of a set of proven practices (the ABCDEF bundle) for adults on breathing machines. About 8,100 patients across multiple ICUs will take part. The goal is t…

This study looks at how the diaphragm—the main breathing muscle—weakens in patients on a breathing machine (mechanical ventilation) in the ICU. Researchers will use mild nerve stimulation and ultrasound to measure muscle strength and brain control over time. The goal is to unders…