MDS

This early-phase study tests a new drug called CG009301 in adults with blood cancers (like leukemia or MDS) that returned or didn't respond to standard treatments. The main goals are to find a safe dose and see if the drug can help control the disease. About 45 participants will …

This study tests whether giving two drugs (decitabine and filgrastim) after a stem cell transplant can safely prevent cancer from coming back in children and young adults with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), or related blood cancers. About 37 partic…

This early-phase trial tests a new cell therapy called BSB-1001 in 38 adults with high-risk blood cancers (AML, ALL, or MDS) who have had a stem cell transplant. The therapy uses specially modified immune cells to target and kill cancer cells that may remain, with the goal of pre…

This early-phase study tests a new drug called eganelisib, given alone or with standard chemotherapy (cytarabine), in about 125 adults whose acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) has returned or not responded to prior treatment. The main goals a…

This study tests whether a cord blood transplant can help children and young adults (up to age 21) with life-threatening blood cancers or genetic blood disorders who do not have a matched family donor. The main goal is to see how many patients survive one year after the transplan…

This study tests whether adding luspatercept to standard EPO therapy helps low-risk MDS patients without ring sideroblasts who did not respond to or cannot take EPO alone. About 150 adults will join this phase 1/2 trial to find the best dose and see if the combination works bette…

This study tests whether adding a precise form of radiation (IM-TMI) to the usual chemotherapy before a stem cell transplant can kill more cancer cells in the bone marrow and lower the chance of the disease coming back. It involves 27 adults aged 18-75 with acute leukemia or myel…

This study tests whether a stem cell transplant from a healthy donor can treat GATA2 deficiency, a genetic condition that weakens the immune system and raises the risk of leukemia. Participants aged 6 to 70 receive chemotherapy or radiation before the transplant to prepare their …

This study tests a stem cell transplant using a milder chemotherapy combination (treosulfan and fludarabine) followed by donor stem cells and drugs to prevent graft-versus-host disease. It includes 132 people aged 2-75 with blood cancers like AML or MDS. The goal is to see if thi…

This early-stage study tests an oral combination of tetrahydrouridine and decitabine in 20 adults with myelodysplastic syndromes (MDS) that relapsed or didn't respond to prior therapy. Participants take the drug once a week for 24 weeks and visit the clinic monthly. The main goal…

This early-stage study tests a pre-made immune cell therapy (MT-401-OTS) for people aged 65+ with relapsed acute myeloid leukemia or high-risk myelodysplastic syndromes. The therapy uses donor T-cells designed to attack multiple cancer-related targets. The main goals are to check…

This study tests a new treatment called CD70-CAR T cells for children and young adults up to age 21 with blood cancers like leukemia, lymphoma, or MDS that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified in a lab to…

This study is developing a new blood test to diagnose a bone marrow disorder called MDS. Currently, diagnosis requires a painful bone marrow biopsy, but this test aims to use a simple blood sample instead. The study will enroll 1500 adults with low blood counts to see if the bloo…

This study looks at adults with advanced myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML) who are receiving palliative care. Instead of giving blood transfusions based only on a fixed hemoglobin level, researchers will use a quality-of-life questionnaire to decide …

This study is a long-term observation of 1,000 patients receiving stem cell transplants for blood diseases at a hospital on the Qinghai-Tibet Plateau. Researchers will collect information on patient health, treatment results, and costs to understand how high altitude affects reco…

This study is creating a large database of people with various blood diseases in China, such as leukemia, multiple myeloma, and hemophilia. Researchers will collect information from medical records and follow participants over time to learn about disease patterns, treatments, out…

This study follows about 1,000 people who previously received an experimental T-cell therapy (TSC-100 or TSC-101) for blood cancers like AML, ALL, or MDS. Researchers will monitor participants for up to 15 years to track any side effects and see how well the therapy works over ti…

This research study aims to discover new genes that may increase the risk of childhood cancer. Researchers will collect blood samples and health information from 1,500 people in families where cancer clusters. The goal is to build a registry and sample bank to help future diagnos…