MDD
Clinical trials for MDD explained in plain language.
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A brain stimulation trial aims to rewire the circuit behind depression
Disease control Not yet recruitingThis trial tests whether transcranial magnetic stimulation (TMS) aimed at a brain circuit linked to the subgenual anterior cingulate cortex can reduce depression symptoms. Adults with major depressive disorder or persistent depressive disorder will receive either active or sham T…
Matched conditions: MDD
Early phase 1 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Could a zap to your face lift your mood? new trial explores FES for depression
Symptom relief Not yet recruitingThis study tests whether Functional Electrical Stimulation (FES) of facial muscles is a safe and effective way to reduce depression symptoms in people with major depressive disorder (MDD). About 60 adults with MDD who have not responded to up to two treatments will receive FES or…
Matched conditions: MDD
Sponsor: Unity Health Toronto • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC