MDD
Clinical trials for MDD explained in plain language.
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Brain training with real-time MRI shows promise for easing depression
Symptom relief CompletedThis study tested a new therapy that uses real-time brain scans (fMRI) to help people with major depression break free from negative thinking patterns. 71 adults with depression participated, and the therapy aimed to reduce depression severity by training the brain to focus less …
Matched conditions: MDD
Phase: NA • Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated May 26, 2026 11:09 UTC
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Virtual reality headsets show promise for easing depression
Symptom relief CompletedThis study tested whether using a virtual reality headset to do enjoyable activities could help ease depression symptoms. 26 adults with major depressive disorder took part. Researchers compared the virtual reality approach to doing similar activities in real life to see which wa…
Matched conditions: MDD
Phase: NA • Sponsor: Stanford University • Aim: Symptom relief
Last updated May 20, 2026 11:54 UTC
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Brain zapping tailored to you: new hope for joyless depression?
Symptom relief CompletedThis study tested a noninvasive brain stimulation technique called accelerated intermittent theta burst stimulation (aiTBS) for people with anhedonic depression—a type of depression where you lose interest or pleasure in things. 60 adults were randomly assigned to receive either …
Matched conditions: MDD
Phase: NA • Sponsor: University of California, San Diego • Aim: Symptom relief
Last updated May 19, 2026 12:00 UTC
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Generic selegiline patch tested against brand in healthy volunteers
Knowledge-focused CompletedThis study tested a generic version of the selegiline skin patch against the brand-name EMSAM in 12 healthy adults. The goal was to see how much of the drug gets into the blood and to check for skin irritation or other side effects. The results help show if the generic patch work…
Matched conditions: MDD
Sponsor: Corium Innovations, Inc. • Aim: Knowledge-focused
Last updated May 19, 2026 11:47 UTC