MCI

This study tests a smart system that reads facial expressions during computer-based brain training to keep older adults (ages 60-89) at risk for Alzheimer's engaged and focused. The goal is to improve long-term adherence to at-home cognitive exercises. Researchers will compare tr…

This early-stage study tests a radioactive dye called [18F]Flortaucipir used in PET scans to see if it can safely help detect Alzheimer's disease. Researchers will study 18 Chinese adults aged 50-85 who are either healthy, have mild cognitive impairment, or have Alzheimer's. The …

This study is testing a new digital platform that uses simple, non-invasive tools like EEG, eye-tracking, and blood flow sensors to find early signs of Alzheimer's disease. It will include 100 people aged 55 to 80, some with mild memory problems and some healthy. The goal is to c…

This study tests a smart virtual reminiscence therapy (SVR) designed to reduce behavioral and psychological symptoms like agitation, anxiety, and depression in older adults with mild cognitive impairment or early dementia. About 60 participants will use the AI-powered talk therap…

This study tests a personalized digital meditation program (MediTrain) in 90 older adults aged 60-85 with mild cognitive impairment (MCI). The goal is to see if it improves sleep quality, reduces stress, and boosts cognitive abilities compared to healthy older adults. Participant…

This study looks at how two common diabetes drug combinations (DPP-4 inhibitors with metformin vs. SGLT2 inhibitors with metformin) affect memory and depression risk in older adults with type 2 diabetes. Researchers will track changes in thinking skills and mood over time using s…

This study aims to find new markers in our DNA, proteins, and metabolism that could help diagnose and track brain diseases like Alzheimer's, Parkinson's, and ALS. Researchers will analyze samples from 1,200 people with these conditions using advanced technology. The goal is to be…

This study is testing a digital meditation program to see if it can improve thinking and reduce stress in older adults. Researchers will enroll 4,000 people aged 60 and older who own a smartphone or tablet. The goal is to find the best amount of meditation needed to help with mem…

This study tests whether a non-invasive brain stimulation technique called TMS can improve working memory in healthy older adults and those with mild cognitive impairment (MCI). Researchers will use brain scans to personalize the stimulation for each participant. The goal is to u…