MASLD

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study tests if a low dose of digoxin, a drug currently used for heart conditions, can help people with NASH (a severe type of fatty liver disease). About 144 adults with NASH and liver scarring will take oral digoxin for a period. The goal is to see if the drug can reverse t…

This study is testing a new, portable device called LiverScope that uses MRI-like technology to check for liver disease without needles or surgery. Researchers want to see if it works as well as standard MRI scans. About 26 adults with fatty liver disease will have one visit that…

This study aims to see if advanced ultrasound techniques can accurately detect fatty liver disease in children, potentially offering a faster, cheaper, and needle-free alternative to MRI. Researchers will enroll 120 children aged 9 to 18 who have risk factors for the condition. T…

This study looks at how much oxalate the body naturally produces in people with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a type of fatty liver. Researchers will measure oxalate levels in urine after participants eat a special low-oxalate diet. The goal is…

This study tests a new care pathway designed to help primary care doctors at VA clinics better identify and treat Veterans with non-alcoholic fatty liver disease (NAFLD), a common but often undiagnosed liver condition linked to obesity and diabetes. The pathway automatically flag…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for diabetes and fatty liver. Thirty adults who have trouble digesting fructose will eat special diets for 12 days each. Researchers will measure changes in g…

This study is looking at the DNA of 2880 people to find genetic clues about why some people with fatty liver disease develop serious liver damage, cirrhosis, or liver cancer. Researchers will compare the genes of patients with advanced disease to those with risk factors but less …

This study looks at how the liver responds to sugar in people with obesity who are having bariatric surgery. Researchers want to compare those with and without a fatty liver condition called MASLD. Participants receive either a sugar solution or salt water during surgery, and sma…

This study aims to see if a special ultrasound done through an endoscope (EUS-SWE) can accurately measure liver scarring (fibrosis) in people with fatty liver disease. About 300 adults will get the new ultrasound, a standard liver biopsy, and a FibroScan. The goal is to find out …