MALIGNANT PLEURAL MESOTHELIOMA

This study tested a way to deliver high doses of three chemotherapy drugs directly to the tumor through an artery in 34 adults with malignant pleural mesothelioma that could not be removed by surgery. The goal was to see if this approach could control the disease and improve surv…

This study tested whether adding the immunotherapy drug durvalumab to standard chemotherapy helps people with advanced pleural mesothelioma live longer. The trial included 214 adults whose cancer could not be removed by surgery. Participants received either the drug combo or a st…

This study tested a new treatment for malignant pleural mesothelioma, a rare and aggressive lung cancer. Six patients received a combination of surgery, light-activated drug therapy (PDT), chemotherapy, and radiation. The goal was to see if this intense treatment plan was safe an…

This study tested a new approach for people with malignant pleural mesothelioma, a rare and aggressive cancer of the lung lining. Participants received a gene therapy virus (rAd-IFN) injected into the chest cavity, along with two drugs (celecoxib and gemcitabine). The goal was to…

This early-phase trial tested a new treatment called CTX131 for adults with several types of advanced solid tumors that had stopped responding to standard therapies. CTX131 uses a patient's own immune cells that are edited with CRISPR technology to target a protein called CD70 on…

This study tested whether giving a short, intense course of radiation to the chest just before surgery can kill cancer cells and prevent them from spreading outside the chest during the operation. It involved 104 people with malignant pleural mesothelioma, a rare cancer linked to…

This study looked back at the medical records of 204 French patients with untreated, inoperable malignant pleural mesothelioma who received a combination of nivolumab and ipilimumab through an early access program. The goal was to see how well the treatment worked in everyday pra…