LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Clinical trials for LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM explained in plain language.
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Can switching PARP inhibitors outsmart cancer? new trial aims to find out
Disease control Recruiting nowThis study is testing a drug called talazoparib in people with advanced solid tumors that have specific DNA repair gene mutations. The goal is to see if this PARP inhibitor can shrink tumors or slow their growth, even in patients who have already tried a similar drug. About 36 ad…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 05:07 UTC
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New drug duo targets hard-to-treat stomach cancers
Disease control Recruiting nowThis early-stage study tests two drugs together for people with HER2-positive stomach cancer or other solid tumors that have spread or can't be removed. The drugs, trastuzumab deruxtecan and azenosertib, aim to kill cancer cells more effectively. The main goals are to find the be…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 05:04 UTC
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New hope for rare cancers: targeted pill shrinks tumors in early trial
Disease control Recruiting nowThis study tests an oral drug called larotrectinib in people aged 16 and older whose advanced solid tumors have too many copies of the NTRK gene. The drug works by blocking enzymes that help cancer cells grow. The main goal is to see how many patients' tumors shrink or disappear.
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 26, 2026 04:59 UTC
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New hope for advanced cancer: immune-boosting drug combined with chemo
Disease control Recruiting nowThis study tests a drug called durvalumab, which helps the immune system fight cancer, when given together with standard chemotherapy. It is for people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the combination is safe and h…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 04:35 UTC
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Custom-Made cancer vaccine shows promise in advanced tumors
Disease control Recruiting nowThis study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated May 22, 2026 14:04 UTC
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New drug targets Hard-to-Treat cancers with specific mutations
Disease control Recruiting nowThis study tests a drug called avapritinib in people with advanced solid tumors that have spread and have specific gene changes (CKIT or PDGFRA mutations). The drug works by blocking enzymes that help cancer cells grow. The goal is to see if avapritinib can shrink or control thes…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 18, 2026 12:07 UTC
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Blood tests may reveal why some cancers resist immunotherapy
Knowledge-focused Recruiting nowThis study looks at how immune cells called T cells change in people with advanced melanoma, lung cancer, or other solid tumors during anti-PD-1 treatment. Researchers will measure specific markers in blood samples to see if they can predict whether the therapy is working or if r…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 26, 2026 05:04 UTC
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Genetic matchmaking for cancer: ComboMATCH trial aims to personalize therapy
Knowledge-focused Recruiting nowThis study screens people with advanced solid tumors to see if their cancer has specific genetic changes. Based on those results, they may be matched to a treatment trial that targets their tumor's unique genetics. The goal is to learn how well these targeted combinations work an…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated May 26, 2026 05:01 UTC