LIPOSOMAL BUPIVACAINE

This study tests a new pain-relief method for people having lung surgery with small incisions (VATS). It combines two numbing medicines, one long-acting, given as a nerve block before surgery. The goal is to see if it reduces pain and the need for extra painkillers in the first 4…

This study tests three different numbing medicines given as nerve blocks during knee replacement surgery. The goal is to see which one provides the best pain relief and reduces the need for strong painkillers. About 90 adults having knee replacement will take part. Results will h…

This study tests if a long-acting painkiller (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after open upper abdominal surgery. About 146 adults having this surgery will receive one of the two drugs injected into the belly lining before the wound …

This study tests whether adding a long-acting numbing drug (liposomal bupivacaine) to the usual numbing medicine reduces pain after laparoscopic surgery better than the usual medicine alone. About 190 adults having gallbladder, hernia, or appendix surgery will take part. The goal…

This study tests three different doses of a long-lasting painkiller (liposomal bupivacaine) injected near the knee nerve to see which works best after total knee replacement. About 177 adults having robotic knee surgery will take part. The goal is to find the dose that reduces pa…

This study compares two pain-relief medicines given during gallbladder surgery to see which one works better and helps patients recover faster. About 86 adults having laparoscopic gallbladder removal will receive either liposomal bupivacaine or ropivacaine as a nerve block. Resea…

This study tests whether a new, long-acting numbing medicine (liposomal bupivacaine) combined with a standard numbing drug can provide better pain relief after laparoscopic surgery than standard care alone. About 318 adults having gallbladder, hernia, or appendix surgery will rec…

This study tests whether a long-acting painkiller (liposomal bupivacaine) plus a standard painkiller works better than the standard painkiller alone for pain after lung surgery. About 100 adults having lung surgery will be enrolled. The goal is to see if the combination reduces t…

This study tests whether a special long-acting numbing medicine (liposomal bupivacaine) injected into the abdominal wall can provide better pain relief for up to 72 hours after laparoscopic gynecologic cancer surgery. About 110 women aged 18-64 will be randomly assigned to receiv…