Knee arthritis, osteoarthritis

Researchers are testing whether a single injection of an experimental gene therapy called GNSC-001 can reduce knee osteoarthritis pain and improve joint function in adults. The trial enrolls about 240 people with moderate knee arthritis confirmed by X-ray. Participants receive on…

This study will compare two treatments—low-level laser therapy and iontophoresis (a method that uses a mild electric current to deliver medication through the skin)—for knee osteoarthritis. Sixty-six adults aged 45 to 65 with mild to moderate knee arthritis will be randomly assig…

This study compares adding electrical dry needling to standard physical therapy versus physical therapy alone for knee osteoarthritis. Forty-four adults aged 40-60 with moderate to severe knee pain will receive treatment for 6 weeks. Researchers will measure changes in pain, knee…

Many older adults with knee osteoarthritis believe their pain comes mainly from joint wear and tear, which can lead to fear of movement and less activity. Researchers at McMaster University are comparing two web-based education programs: one that explains pain as a mix of biologi…

This study investigates whether the thickness of fat over the shin bone, measured on a standard knee X-ray, is a better predictor of infection after total knee replacement than Body Mass Index (BMI). Researchers will review data from 400 adults who had knee replacement surgery, c…

This study will follow 100 adults with knee arthritis who are scheduled for knee replacement surgery. Researchers will measure how changes in the shape of the knee bones after surgery affect how well the knee bends and how much pain patients feel. The goal is to find the best ali…