KAPOSI SARCOMA

This study tests whether propranolol, a safe oral drug used for heart conditions, can shrink Kaposi sarcoma tumors in adults. About 25 participants with measurable skin lesions will receive the drug, and researchers will check if at least 45% of patients see their tumors shrink o…

This study is testing a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the combo can shrink tumors or stop them from growing. Pa…

This study tests a lab-made human protein called CYT107 in 55 adults with HIV-related Kaposi sarcoma. The goal is to see if weekly injections for 4 weeks can shrink skin tumors by boosting the immune system. Participants who improve may receive another round of treatment within a…

This study tests a drug called ixazomib in 41 people with Kaposi sarcoma, a type of skin cancer. The drug works by blocking enzymes that help cancer cells grow. The goal is to see if it can shrink tumors and control the disease.

This study tests a drug called abemaciclib, already used for breast cancer, in people with Kaposi sarcoma (KS). It includes both HIV-positive and HIV-negative adults with at least five measurable skin lesions. The goal is to find a safe dose and see if the drug can shrink tumors …

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control tumors for at least 12 months. About 28 adults who have not responded to standard treatments will take part.

This early-stage study tests a new treatment called MQ710, made from a modified virus, for people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors, either alone or with the immunotherapy drug pembrolizumab. T…

This study tests two immunotherapy drugs, PDS01ADC and M7824, for people with advanced Kaposi sarcoma (KS) that has not responded well to prior treatment. The drugs work by helping the immune system recognize and attack KS tumors. About 80 adults will receive the drugs for up to …

This study tests a new 3D imaging device called SkinScan3D to see if it can take better pictures of Kaposi sarcoma lesions than standard 2D photos. The device uses special lenses and AI to measure the height and volume of skin lesions, which may help doctors detect treatment resp…

This study looks at whether peer-to-peer education and support can help more young people (ages 15-39) living with HIV get screened for and treated for certain cancers. About 4,100 participants in Zambia will take part. The goal is to see if this approach increases the number who…

This study follows 150 adults with Kaposi sarcoma (KS) for up to 10 years to learn how the disease behaves over time. Researchers will track whether tumors go away, come back, or spread, and how the immune system responds. Participants continue their usual KS treatment and underg…