IRRITABILITY
Clinical trials for IRRITABILITY explained in plain language.
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New therapies target childhood anger and irritability
Symptom relief Recruiting nowThis study is testing two different talk therapy approaches to help children and teenagers with severe irritability and frequent temper outbursts. Researchers want to see if Cognitive Behavioral Therapy (CBT) or a computer-based training program called Interpretation Bias Trainin…
Matched conditions: IRRITABILITY
Sponsor: National Institute of Mental Health (NIMH) • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Brain scans may reveal best ADHD treatment for aggressive kids
Knowledge-focused Recruiting nowThis study aims to find brain activity patterns that can predict which children with ADHD and significant aggression or irritability will improve with stimulant medication. Researchers will enroll 136 children, ages 8-12, to have their stimulant dose optimized and then test their…
Matched conditions: IRRITABILITY
Phase: PHASE4 • Sponsor: Milton S. Hershey Medical Center • Aim: Knowledge-focused
Last updated Apr 02, 2026 14:56 UTC
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Scientists probe Antidepressant's hidden effect on healthy minds
Knowledge-focused Recruiting nowThis University of Oxford study aims to understand how the antidepressant fluoxetine (Prozac) affects how healthy young people process anger. 80 participants aged 18-24 will take either a 20mg fluoxetine pill or a placebo daily for one week and complete tasks designed to measure …
Matched conditions: IRRITABILITY
Phase: NA • Sponsor: University of Oxford • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:32 UTC
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Scientists scan brains to unlock secrets of frustration
Knowledge-focused Recruiting nowThis study aims to understand how the brain responds to frustration in healthy adults. Researchers will use brain scanning technology (MRI and MEG) while participants play a computer game designed to be frustrating. The goal is to map which brain circuits become active during fru…
Matched conditions: IRRITABILITY
Phase: EARLY_PHASE1 • Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated Mar 11, 2026 14:53 UTC