INFERTILITY, FEMALE

This study compares two ways to prepare the uterus for a frozen embryo transfer: a natural cycle with added progesterone and a hormone replacement therapy cycle. The goal is to see which method leads to more live births. The study will include 336 women aged 21-44 with regular ov…

This study tests a simpler, lower-cost version of IVF called in-vitro oocyte maturation (IVM) for women with infertility or those needing fertility preservation. Instead of strong hormone shots, eggs are collected early and matured in a lab. The goal is to see how many mature egg…

This study tests a device that uses ultrasound to carefully remove a small part of the ovary in women with PCOS who have trouble getting pregnant. The goal is to help them ovulate naturally again. About 195 women aged 18 to 40 will take part to see if the procedure is safe and ef…

This study compares a single long-acting injection (corifollitropin α) to daily hormone shots for ovarian stimulation in egg donors. The goal is to see if the simpler approach works just as well while reducing the physical and emotional burden of daily injections. About 318 healt…

This study tests whether giving a GnRH agonist hormone injection before a frozen embryo transfer can improve pregnancy rates in women with endometriosis or adenomyosis. About 180 women aged 18-36 will be randomly assigned to receive either the hormone plus standard estrogen/proge…

This study tests whether a mindset management program called Organic Conceptions can reduce stress in women dealing with infertility. About 66 new patients at a fertility clinic will be split into two groups: one takes the program, the other does not. All participants fill out st…

This study tests whether taking Gushen Antai pills (a traditional Chinese herbal medicine) can improve the chance of an ongoing pregnancy in women with normal egg supply who are doing IVF for the first time. About 800 women will be randomly assigned to receive either the herbal p…

This study tests whether a smartphone app with daily mindfulness exercises can reduce anxiety in women undergoing in vitro fertilization (IVF). About 150 women will either use the app for 15 minutes each day during their treatment or receive standard care. Researchers will measur…

This study compares a longer course of the fertility drug Clomid against the standard 5-day protocol for women with diminished ovarian reserve who are undergoing IVF. The goal is to see if the extended protocol helps retrieve more mature eggs while reducing the number of injectio…

This study tests whether tadalafil, a drug that improves blood flow, can help women with unexplained infertility have better pregnancy outcomes during IVF. About 100 women with good-quality frozen embryos will take tadalafil to see if it thickens the uterine lining and increases …

This study tests whether taking a low dose of the hormone hCG for eight weeks before IVF can help women with low ovarian reserve produce more eggs. About 80 women aged 18-40 will be randomly assigned to receive either hCG or a placebo before their second IVF cycle. The main goal …

This study looks at how women's feelings about artificial intelligence relate to their anxiety levels and quality of life while undergoing infertility treatment. About 191 women aged 18-45 with infertility will answer questionnaires. The goal is to understand these connections to…

This study watches blood sugar patterns in 100 women getting fertility treatments like IVF. Participants wear a continuous glucose monitor to track sugar levels around the clock. The goal is to see if these sugar changes affect pregnancy success.

This study looks at whether measuring telomeres (a marker of biological aging) can help explain why some women remain infertile even after standard treatments like IVF. Fifteen women aged 25 to 42 will receive a personalized plan combining traditional Chinese medicine, nutrition,…

This study looks at whether chlordecone, a pesticide still present in the environment in Guadeloupe, is linked to lower fertility in women. Researchers will measure levels of the chemical in 634 women seeking help for infertility and check their ovarian reserve using a hormone te…

This study looks at immune cells in the womb lining and blood of 50 women with normal or reduced fertility (including those with unexplained infertility or recurrent miscarriage). Researchers want to see if differences in these cells help explain why some women struggle to get pr…

This study looks at how physical activity, fitness, and mental health influence pregnancy rates in women receiving fertility treatments like IVF. Researchers will track 115 women's exercise habits, stress levels, and heart health to see if these factors improve their chances of g…

This study looks at whether the amount of a hormone called AMH in the fluid around a woman's egg can tell us if the resulting embryo has the right number of chromosomes. Researchers will collect fluid from the first egg follicle of each ovary during egg retrieval for IVF. They wi…

This study looks at freezing ovarian tissue to preserve fertility in girls who need treatments that could harm their ability to have children later. About 40 girls with cancer or other health conditions will be included. Researchers will track how many use the tissue and at what …

This study looks at two ways to fertilize eggs with frozen donor sperm: ICSI (injecting a single sperm into each egg) and conventional IVF (mixing eggs and sperm in a dish). About 95 women undergoing IVF at Shady Grove Fertility Center will have their eggs split into two groups, …

This study aims to better understand cervical mucus, a fluid that helps sperm travel and protects the female reproductive tract. Researchers will use infrared spectroscopy to find biomarkers that could help diagnose or predict reproductive problems. They will compare healthy wome…

This study looks at how different ovarian stimulation protocols affect blood clotting and breakdown in women with infertility. Researchers will compare changes in clot properties before and after treatment, including in women with endometriosis. The goal is to understand risks an…