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Fertility showdown: does injecting sperm beat mixing in a dish?

NCT ID NCT07175571

Knowledge-focused Sponsor: Shady Grove Fertility Reproductive Science Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at two ways to fertilize eggs with frozen donor sperm: ICSI (injecting a single sperm into an egg) and conventional IVF (mixing eggs and sperm in a dish). About 95 women without male fertility issues will have their eggs split into two groups, one fertilized with each method. Researchers want to see which method creates more usable embryos and whether one leads to better fertilization or early pregnancy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)
What this could lead to
If it works, this could help doctors choose the best fertilization method for people using frozen donor sperm, potentially improving embryo quality and pregnancy chances.
What could go wrong
This is a small, early-stage study (95 participants) comparing two procedures, not testing a new treatment. Results may not apply to all fertility cases, and there is no guarantee of better pregnancy outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 95 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2025

An estimate. Start dates often move.

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients undergoing IVF with frozen donor sperm at Shady Grove Fertility Center * Normal ovarian reserve (AMH \> 1 ng/mL, AFC \> 10) * Absence of male factor infertility * Post-wash parameters: \>50% motility, \>5mil concentration * \> 4 oocytes retrieved at time of transvaginal oocyte retrieval Exclusion Criteria: * Donor Sperm with significant male factor infertility (e.g., abnormal sperm concentration, motility, or morphology) * Any medical condition contraindicating ART

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Conditions

The condition(s) this trial relates to.

female infertility Helping Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fertilization in vitro Infertility, female Reproductive techniques, assisted

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shady Grove Fertility Rockville

    RECRUITING

    Rockville, Maryland, 20850, United States

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