IGA NEPHROPATHY (IGAN)

This Phase 2 trial tests an experimental drug called SLN12140 in 48 adults with IgA nephropathy, a kidney disease that is not well controlled by standard treatments. Participants receive different doses of SLN12140 or a placebo by injection for 36 weeks, followed by an open-label…

This early-phase study tests a new treatment using specially engineered immune cells (CD19 CAR-γδ T cells) for people with severe autoimmune kidney diseases like lupus nephritis, IgA nephropathy, and membranous nephropathy that haven't responded to standard therapies. About 15 pa…

This study tests whether Shenqi Yishen Granules, a traditional Chinese medicine, can reduce protein in the urine of adults with IgA nephropathy, a kidney disease. Researchers will compare the granules to a placebo in 102 participants over several months. The goal is to see if the…

This study tests whether a low dose of Nefecon (8 mg) can prevent proteinuria relapse in people with IgA nephropathy who have already responded to treatment. About 288 adults who completed 9 months of Nefecon therapy and have low protein levels will take either Nefecon or a place…

This early-phase study tests a new cell therapy called GT719 in about 30 adults with kidney diseases caused by the immune system, such as IgA nephropathy and membranous nephropathy. The treatment is given as an injection, and the main goals are to check if it is safe and to find …

This study will follow 50 adults with IgA nephropathy who are taking sparsentan. Researchers want to see how the drug affects protein in the urine (albuminuria), a key sign of kidney damage. The study is observational, meaning it just watches what happens in real-world use, witho…

This early-stage study tests a single injection of RG002C0106 in 24 adults to see how kidney function affects the drug's levels and safety. Participants have either normal kidneys or mild-to-moderate kidney impairment. The goal is to gather basic information, not to treat the dis…

This study looks at what changes occur in the kidneys, urine, and blood when people with IgA nephropathy (IgAN) experience loin pain. Researchers will use MRI scans and lab tests to compare findings during a pain episode and when pain-free. The goal is to better understand the ca…