IBS - IRRITABLE BOWEL SYNDROME

This study tests whether adding a dietary supplement called NAC to the standard IBS-D drug rifaximin can better relieve stomach pain and diarrhea. About 225 adults with IBS-D will receive either the combination or a placebo. The goal is to see if NAC helps break down mucus in the…

This study tests whether low-frequency magnetic pulses aimed at a specific brain region can reduce chronic abdominal pain in people with irritable bowel syndrome with diarrhea (IBS-D). 42 adults with IBS-D will receive either real or sham stimulation over two weeks, with neither …

This study tests whether a probiotic called Saccharomyces boulardii can reduce symptoms of irritable bowel syndrome (IBS) in adults. About 406 people with non-constipated IBS will take either the probiotic or a placebo daily for 8 weeks. Researchers will measure changes in sympto…

This early study at Mayo Clinic tests whether adding a medication called mirtazapine to a low-FODMAP diet works better than diet alone for easing IBS with diarrhea. About 20 adults aged 18-70 will take part. The goal is to reduce belly pain, bloating, and improve stool consistenc…

This study tests whether a daily drink mix containing special sugars (HMO-2FL) and a postbiotic can reduce stomach pain, bloating, and other IBS symptoms. About 402 adults with IBS will take either the supplement or a placebo for 6 weeks. Researchers will compare symptom scores t…

This study tests whether a daily enzyme supplement (FODZYME®) can reduce bloating and stomach pain in adults who often feel bloated. About 150 people will take either the enzyme or a placebo for a period, then switch, to see if the enzyme helps break down hard-to-digest carbs. Th…

This study tests a non-invasive belt-like device (Variable Compression System) for people with moderate to severe Irritable Bowel Syndrome (IBS). Twenty participants will wear the device for at least 6 hours daily to see if it safely reduces IBS symptoms like pain, bloating, and …

This study tests whether ebastine, an allergy medication, works better than mebeverine, a common IBS drug, for reducing belly pain and improving daily life. About 200 adults with non-constipated IBS will take one of the two pills for 12 weeks. The goal is to see if ebastine provi…

This observational study is looking at the gut microbiome of 315 people, including those with irritable bowel syndrome that started after an infection. Researchers will compare their gut bacteria to people who had an infection but no IBS, and to healthy controls. The goal is to f…

This study aims to find out how many relatives of people with celiac disease have non-celiac wheat sensitivity (NCWS) or irritable bowel syndrome (IBS) not caused by wheat. Researchers will ask 600 adult relatives to follow a wheat-free diet for 6 weeks and complete online questi…

This study looks at people with Irritable Bowel Syndrome (IBS) who have a reduced ability to break down starch and sugar due to low enzyme levels. Researchers want to see if these individuals have a smaller rise in blood sugar after a meal and more bowel symptoms compared to thos…