HSCT

This study tests a new drug called zuberitamab for people who develop Epstein-Barr virus (EBV) infection after a stem cell transplant. EBV can cause a serious condition called PTLD, which can be deadly if not treated. The drug targets a protein on infected cells to help clear the…

This study tests a lower dose of the chemotherapy drug treosulfan before a stem cell transplant in 24 people with Nijmegen Breakage Syndrome, a rare genetic condition that weakens the immune system and raises cancer risk. The goal is to see if this approach can improve survival b…

This study tests if the drug luspatercept can improve anemia in 20 adults with blood cancers who have had a stem cell transplant. The main goal is to see if it reduces the need for red blood cell transfusions. Participants will receive the drug and be monitored for side effects a…

This study tests a drug called gecacitinib in 33 adults who have chronic graft-versus-host disease (cGVHD) after a stem cell transplant and whose condition did not improve with steroids. The goal is to see if the drug can safely control the disease and reduce symptoms. Participan…

This study tests a milder chemotherapy combination (thiotepa and melphalan) given before a stem cell transplant for people with blast phase chronic myeloid leukemia, an advanced and hard-to-treat form of the disease. The goal is to improve survival while reducing serious side eff…

This study tests whether a combination of two drugs (olverembatinib and inotuzumab ozogamicin) can clear remaining leukemia cells in adults with a specific type of acute lymphoblastic leukemia (Ph+ ALL) who still have detectable disease after initial treatment. The goal is to ach…

This study tests whether giving focused radiation (SBRT) to tumors outside the bone marrow before a donor stem cell transplant can improve survival and reduce cancer return in adults with blood cancers. About 20 participants aged 18-60 will be enrolled. The goal is to see if this…

This study tests whether the drug gecacitinib, given before, during, and after a stem cell transplant, can help people with myelofibrosis (a rare bone marrow cancer) live longer without serious complications like graft-versus-host disease or relapse. About 39 adults aged 18-75 wi…

This study tests if a lower dose of a drug called cyclophosphamide can reduce side effects after a stem cell transplant from a half-matched donor in people with blood cancers. About 180 adults will be randomly assigned to receive either the standard or a reduced dose. The goal is…

This study will follow 400 people receiving a stem cell transplant for blood cancers to learn why some develop serious heart problems like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, EKGs, and blood tests to find early warning signs. Th…

This study follows 100 children in Denmark who receive a stem cell transplant for serious blood diseases. Researchers will test their thinking, memory, and physical abilities before the transplant and for one year after. The goal is to learn which medical, physical, and environme…