HPV-RELATED CARCINOMA

This study tests a new 15-valent HPV vaccine to see if it is safe and triggers a strong immune response. It involves 330 healthy Chinese volunteers aged 9 to 45. Participants receive three doses of the vaccine or a placebo, and researchers monitor side effects and antibody levels…

This study tests an experimental vaccine that targets 11 types of HPV, the virus that causes cervical cancer. About 13,500 Chinese women aged 18-45 will receive either the vaccine or a placebo over 6 months. The goal is to see if the vaccine prevents serious cervical cell changes…

This study tests whether adding an experimental drug (PRGN-2009) to the existing immunotherapy pembrolizumab can shrink tumors in people with advanced cervical cancer that no longer responds to pembrolizumab alone. About 24 adults with HPV-positive, recurrent or metastatic cervic…

This study is for people with HPV-related throat cancer who have had or will have surgery to remove the tumor. Researchers will use a blood test to look for tiny bits of cancer DNA (ctDNA) to see if the cancer is likely to come back. The goal is to find out if some patients can s…

This study tests a new immunotherapy for people with advanced HPV-related cancers (cervical, throat, anal, and others). Doctors take a patient's own immune cells, add a special receptor to help them find and attack HPV-infected cancer cells, and give them back. The goal is to shr…

This study tests whether a single dose of a patient's own genetically modified immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before standard treatment like chemo-radiation or surgery. About 15 adults with advanced HPV-positive cancers (e.g., cervical, …

This study is testing a new mouth swab test that looks for HPV DNA and certain gene changes to find throat cancer early. Researchers will compare results from 200 people with throat cancer and 200 healthy volunteers matched by age, sex, and background. If the test works well, it …

This study looks at whether HPV DNA can be found in the blood of people with HPV-related anal or cervical cancer before, during, and after radiation therapy. Researchers will collect blood samples and tumor tissue to see if changes in HPV DNA levels can help predict if the cancer…

This study is testing a new, low-cost blood test that looks for tumor DNA from HPV-related cancers (cervical and anal) after standard radiation treatment. The goal is to see if this simple test can replace expensive scans and biopsies for monitoring patients, and to identify thos…