HER2 + BREAST CANCER

This study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment will take the drug al…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to a single spot where breast cancer has worsened can help keep the disease from spreading further. Participants continue their usual drug therapy while receiving SBRT. The goal is to see if this appr…

This early-stage trial tests a new radioactive drug called [177Lu]Lu-ABY-271 in people with HER2-positive metastatic breast cancer that has spread and cannot be removed by surgery. The main goals are to check safety and see where the drug travels in the body. About 21 participant…

This study tests whether adding elacestrant to standard chemotherapy (capecitabine) can help people with advanced estrogen receptor-positive (ER+) breast cancer that no longer responds to CDK 4/6 inhibitors. About 297 participants will be randomly assigned to get either the combi…

This study tests a new combination of drugs given before surgery for people with HER2-positive breast cancer. About 50 participants will receive the drugs to see if the tumor shrinks enough to avoid more chemotherapy. If the tumor does not shrink enough, patients will switch to a…

This study tests whether combining two experimental drugs (HLX22 and HLX87) works better than standard treatment for people with HER2-positive breast cancer that has returned or spread. About 706 adults will take part. The main goals are to see if tumors shrink and how long the c…

This early-phase trial tests an experimental drug called IAM1363 in people with advanced cancers that have HER2 alterations. The study aims to find a safe dose and see if the drug can shrink tumors, including those that have spread to the brain. About 383 adults whose cancer has …

This study will follow 1000 people with HER2-positive breast cancer to learn how patient and tumor features affect long-term survival and treatment response. Researchers will track survival rates and whether tumors disappear completely after pre-surgery therapy. The goal is to ga…

This study is collecting tissue and blood samples from 500 people with breast cancer who are receiving treatment before surgery. Researchers will analyze these samples to learn why some cancers respond well to therapy while others do not. The goal is to find better ways to predic…

This study looks at whether a simple blood test can find tiny bits of cancer DNA left in the body after breast cancer treatment. Finding this DNA, called minimal residual disease, may help predict if the cancer will come back. The study will follow 900 people with different types…