HER2
Clinical trials for HER2 explained in plain language.
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New pill takes aim at hard-to-treat HER2 cancers
Disease control Recruiting nowThis early-stage trial tests a new drug called IAM1363 in adults with advanced cancers that have HER2 alterations, including breast, lung, and stomach cancers that have spread to the brain. The study aims to find the safest dose and see if the drug can shrink tumors. About 383 pa…
Matched conditions: HER2
Phase: PHASE1 • Sponsor: Iambic Therapeutics, Inc • Aim: Disease control
Last updated Jun 22, 2026 12:06 UTC
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New pill targets Hard-to-Treat cancers with brain spread
Disease control Recruiting nowThis early-phase study tests a daily oral drug called CGT4255 in 100 adults with advanced solid tumors that have ERBB2 genetic changes or HER2 overexpression. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors, including in the brain. The …
Matched conditions: HER2
Phase: PHASE1 • Sponsor: Cogent Biosciences, Inc. • Aim: Disease control
Last updated Jun 22, 2026 11:55 UTC
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New hope for hard-to-treat ovarian cancer: targeted drug combo enters trial
Disease control Recruiting nowThis study tests a new drug called distamab vedotin (RC48) combined with carboplatin for people with advanced ovarian cancer that has a specific protein called HER2. The goal is to see if this combination works better and causes fewer side effects than standard chemotherapy. Abou…
Matched conditions: HER2
Phase: PHASE2 • Sponsor: Zhejiang Cancer Hospital • Aim: Disease control
Last updated Jun 18, 2026 11:53 UTC
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New hope for hard-to-treat cancers: triple-drug combo targets HER2-positive tumors
Disease control Recruiting nowThis study tests a combination of three drugs (trastuzumab, serplulimab, and chemotherapy) in 20 adults with advanced bile duct or bladder cancers that have stopped responding to standard treatments. The goal is to see if this approach can shrink tumors and improve survival. Part…
Matched conditions: HER2
Phase: PHASE2 • Sponsor: Xiujuan Qu • Aim: Disease control
Last updated Jun 08, 2026 13:17 UTC
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New imaging agent could sharpen view of HER2 cancers
Diagnosis Recruiting nowThis early-phase study tests a radioactive tracer called [68Ga]Ga-ABY-025 for PET scans in 30 adults with advanced HER2-positive cancers (breast, stomach, head/neck, esophageal). Participants receive the tracer and a PET/CT scan while on standard HER2-targeted therapy. The main g…
Matched conditions: HER2
Phase: EARLY_PHASE1 • Sponsor: Vanderbilt-Ingram Cancer Center • Aim: Diagnosis
Last updated Jun 22, 2026 11:59 UTC
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Italian study maps HER2 mutations in advanced lung cancer
Knowledge-focused Recruiting nowThis observational study will track 50 people with advanced non-small cell lung cancer (NSCLC) in Italy to see how common HER2 mutations are and how doctors currently treat them. Participants will be followed for one year. The goal is to understand real-world care, not to test a …
Matched conditions: HER2
Sponsor: Gruppo Oncologico Italiano di Ricerca Clinica • Aim: Knowledge-focused
Last updated Jun 22, 2026 11:54 UTC