HEMATOPOIETIC AND LYMPHOID SYSTEM NEOPLASM

This study is for people with certain blood cancers (like CLL or lymphoma) who are starting a type of drug called a BTK inhibitor. These drugs can raise blood pressure and increase the risk of heart problems. The study will test if carefully managing high blood pressure can lower…

This study is for people with certain blood cancers (like leukemia) that have a specific genetic change called an IDH1 mutation. It tests a combination of two or three drugs: ivosidenib (targets the mutation), venetoclax (blocks a protein that helps cancer cells survive), and som…

This study tests the safety and best dose of bendamustine, given with or without cyclophosphamide, to prevent graft-versus-host disease (GVHD) in people with blood cancers who receive a stem cell transplant. About 25 participants will receive the drug after transplant, along with…

This study tests whether giving a CMV vaccine to stem cell donors can protect transplant recipients from CMV infection. Donors receive the vaccine before donating stem cells, and the immunity is passed to the patient. The trial involves 216 people with blood cancers and aims to r…

This study looks at whether a spinal cord stimulation device can reduce pain and improve daily life for people with nerve damage caused by chemotherapy. About 20 adults who have had chemo-related nerve pain for over six months will receive the treatment. Researchers will track pa…

This study compares giving cancer treatment at home versus in a clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves the overall experience. About 220 participants will be randomly assigned to receive their t…

This study looks at whether a low-intensity vibration board can help blood cancer patients who are planning to have a stem cell transplant or immune cell therapy. The vibrations may strengthen bones and improve muscle function, and might also boost the body's immune cells. Resear…

This study tests a community-based exercise program for cancer survivors who have finished active treatment. Researchers partner with the YMCA to offer tailored home workouts. The goal is to see if this program is practical and helps improve quality of life. About 200 participant…

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study tests a program called ASCENT that helps cancer survivors manage pain using an educational guide and coaching from community health workers and pain care managers. The goal is to improve pain and reduce the risk of opioid misuse. The study will include 660 adults with …

This study tests if a virtual group therapy program, combining Acceptance and Commitment Therapy (ACT) and compassion-based techniques, can improve psychological well-being in cancer patients. Researchers will enroll 200 adults at Mayo Clinic Arizona who have a cancer diagnosis o…

This study tests whether a telemedicine program can help older adults (65+) with cancer get care that matches their needs and goals. Researchers will use a special health assessment to find areas of weakness and connect patients with a team of experts. The goal is to see if this …

This study looks at how cancer patients and their doctors discuss immunotherapy. Researchers want to understand where patients get information, what they know, and how doctors explain the treatment. They will also test if educational videos can improve patient understanding. The …

This study collects and analyzes genetic material (DNA, RNA) and tissue samples from 500 adults with cancer to identify markers and causes of the disease. Researchers will build a biobank to explore better ways to prevent, detect, and treat cancer. Participants must have a confir…

This study looks at whether a 6-week group program can help young adults (ages 18-39) who have finished cancer treatment feel more prepared for daily life. Participants will attend group meetings led by social workers and complete surveys about their quality of life and mental we…

This study offers free genetic testing to the general public to find people with inherited cancer syndromes like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500 …

This study looks at a new way to help family members of people with inherited cancer get tested for the same gene changes. About 15% of cancers are inherited, but many people don't know they carry a risky gene. The study will test if having a doctor reach out to at-risk relatives…

This study aims to find normal levels for a new blood and urine test that looks for DNA markers of cancer. Researchers will collect samples from 10,000 adults without known cancer to establish a baseline. The goal is to improve future cancer screening methods.