HEMATOLOGIC DISEASES

This study tests whether adding the drug vorinostat to standard care can lower the chance of graft-versus-host disease (GVHD) in children, teens, and young adults getting a bone marrow or blood stem cell transplant for blood cancers. About 43 participants will receive vorinostat …

This study follows 160 children and adults with beta-thalassemia or sickle cell disease who already received an experimental CRISPR gene therapy called CTX001. Researchers will track participants for years to check for long-term side effects, new cancers, and how well the treatme…

This study tests a single dose of CTX001, a gene therapy made from the patient's own blood stem cells edited with CRISPR, in 16 children with transfusion-dependent beta-thalassemia. The goal is to see if it can help them produce enough healthy red blood cells to stop needing regu…

This study was designed to test an experimental drug called HMPL-523 in adults with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding problems. The goal was to see if the drug is safe and can raise platelet counts. However, th…

This study looks at how blood cancers and stem cell transplants affect muscle function in 144 patients. Researchers want to see if muscle health can help predict complications like infections, relapse, or survival. The goal is to better understand the role of muscle strength at k…

This study follows over 32,000 people who helped clean up the 2010 Deepwater Horizon oil spill or lived in affected areas. Researchers compare their health to people who were not exposed, using medical exams, lab tests, and phone interviews every two years. The goal is to learn a…

This small study tests whether frozen testicular tissue can be transplanted back into men to produce sperm. It includes men with infertility and healthy volunteers. The goal is to see if this approach could one day preserve fertility for boys who lose it due to cancer treatment.

This study tests a new digital platform that helps hospitals share patient information more reliably when a patient is transferred from one hospital to another. About 1,000 adults being moved to Brigham and Women's Hospital from three other hospitals will take part. The goal is t…

This study gathers medical information from up to 10,000 people with blood or lung conditions, as well as stem cell donors. Researchers will review participants' medical records, test results, and treatments to build a database for future research ideas. The goal is not to test a…

This study collects blood and tissue samples from people receiving bone marrow transplants and their donors. Researchers will analyze these samples to find genes and proteins linked to cancer. The goal is to better understand why some patients develop complications or have differ…