Heart valve diseases

This study tests whether the Edwards EVOQUE system, a valve replacement delivered through a catheter, can safely and effectively treat tricuspid regurgitation, a condition where the tricuspid valve fails to close properly. Researchers will enroll 500 adults in Europe who are deem…

This study tests a new device called the VDyne System, which is placed inside the heart through a tube in a blood vessel to replace a leaky tricuspid valve. The trial will include 730 people with severe symptoms who have not improved with medication. Researchers will compare the …

This early study is testing a new device called the TRiCares Topaz, which is threaded through a vein to replace the tricuspid valve in the heart. It is for adults with severe tricuspid valve leakage who are not good candidates for open-heart surgery. The study will check if the d…

This study is testing a new type of biological heart valve that features an 'easy change' system, designed to make future replacements simpler. Researchers will implant these valves in 500 people with aortic valve disease and track complications like blood clots, infections, and …

This early study is testing a new device called the DUO System, which is placed through a catheter to reduce leakage in the tricuspid valve. The study will include 15 people with severe tricuspid regurgitation who still have symptoms despite medical therapy. The main goal is to s…

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein to help the valve close better, reducing blood backflow. The goal is to see if it improves symptoms, walking ability, and …

This study tests an artificial intelligence (AI) model that can screen for heart valve disease using standard chest CT scans that people already get for other reasons. The goal is to see how well the AI catches moderate-to-severe cases without needing extra tests or contrast dye.…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

This study trains non-expert staff in GP practices to perform quick heart ultrasounds on people 65 and older. The goal is to find hidden heart valve disease or heart failure early, especially in diverse communities. Researchers hope this approach can reduce emergency hospital vis…

This study will give heart ultrasounds to 1050 nursing home residents to see if catching heart problems early reduces flare-ups and unplanned hospital stays. Researchers will also check if the scans are practical and affordable for nursing homes. The goal is to improve heart care…

This study tests a new paired-ring sizing tool used during mitral valve repair surgery. The tool measures the length of leaflet coaptation, which is how well the valve leaflets seal. Researchers want to see if this method gives accurate measurements compared to standard echocardi…

This observational study tests a new spectroscopic device designed to measure oxygen levels in the heart muscle during open-heart surgery. The goal is to see if the device can safely record this data and how it relates to surgical events and patient parameters. Participants are a…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This study is a large registry that will follow 10,000 people who have had a procedure called TAVR to replace a faulty heart valve. The goal is to see how patients do over the long term in everyday medical practice. No new treatment is being tested; instead, researchers are colle…