Head and neck cancer (H&N)

This trial tests whether a special dye called indocyanine green (ICG), injected during surgery, helps surgeons see blood flow in reconstructed tissue better than standard checks. About 244 adults having head and neck reconstruction will be randomly assigned to get the dye or stan…

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This early-phase study will test two radioactive tracers designed to light up certain solid tumors on scans. Twenty adults with breast, head and neck, pancreatic cancer, or glioma will receive an injection of the tracers and then undergo PET/CT and SPECT/CT imaging. The goal is t…

This study will test artificial intelligence algorithms that analyze video from routine endoscopies of the head and neck. The AI will try to detect, classify (benign vs. malignant), and outline lesions, comparing its performance to doctors and lab results. About 283 adults with s…

This pilot study tests whether placing a soft tissue matrix over a nerve during forearm flap surgery can prevent chronic pain and numbness. Eighty head and neck cancer patients will be randomly assigned to receive either the matrix or standard closure. The main goal is to see if …

This trial tests whether a structured swallowing rehabilitation program can improve swallowing function, reduce jaw stiffness, and ease pain in people with head and neck cancer. Researchers will randomly assign 80 patients who have had radiation or chemoradiotherapy to either the…

This study tests whether a 10-week home-based video game training program can improve cognitive function and driving performance in head and neck cancer survivors who report thinking difficulties after radiation or chemoradiation. Participants will complete questionnaires, use a …

This study tests whether daily soaks with normal saline (salt water) can reduce severe skin reactions caused by radiation therapy. About 150 adults with head and neck cancer or sarcoma will either get standard care or standard care plus a 5-10 minute saline soak each day. Researc…

This study looks at whether changes in regulatory T cells (a type of immune cell) after facial reconstruction surgery can predict how quickly patients heal and how long they stay in the hospital. Researchers will collect blood samples from about 60 adults before, during, and afte…

This pilot study will test whether trained community health navigators can help head and neck cancer patients get diagnosed and treated faster after an emergency room visit. The navigators will call or text patients to help with barriers like transportation, insurance, or housing…