HARM REDUCTION

This study will test whether e-cigarettes or a natural supplement called cytisine can help people who smoke at least 5 cigarettes a day and haven't been able to quit with standard treatments like nicotine patches or counseling. Over 4 years, 6,000 participants will be randomly as…

This study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…

This study tests whether four short counseling sessions can help people who misuse anabolic steroids reduce their use and improve their health. Researchers will track 32 participants for a year, looking at drug use, blood tests, mood, and body changes. The goal is to see if a non…

This pilot study tests a one-time 'booster' session for people who inject drugs and their injecting partners, given right after finishing hepatitis C treatment. The session helps them set health goals, identify barriers, and improve communication to stay engaged in ongoing health…

This study tests a computer alert that notifies doctors when a patient is about to move into a new phase of opioid therapy, such as from short-term to long-term use. The alert encourages doctors to review the patient's pain and goals, following CDC guidelines. Researchers will st…

This study will test if a new technology tool is helpful for people living in supportive housing who also have substance use issues. The tool includes videos and rewards to teach life skills and coping strategies. Researchers want to see if residents find it easy to use and if it…

This study tests whether a computer alert can help doctors identify and treat patients with opioid use disorder. About 200,000 adults will be involved, and doctors will either get an alert or not. The goal is to see if the alert increases the use of medications like buprenorphine…