HAEMATOLOGICAL MALIGNANCY

This study tests a new oral drug called CCS1477 (inobrodib) in people with advanced blood cancers such as acute myeloid leukemia, non-Hodgkin lymphoma, multiple myeloma, and high-risk myelodysplastic syndrome. The drug is given alone or with other cancer medicines. The goal is to…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare or hard-to-treat cancers will receive …

This trial tests capmatinib, a drug already approved for certain lung cancers, in adults with rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if it can shrink tumors or stop them from growing for at least 24 weeks. The goal is …

This trial is testing a drug called entrectinib (Rozlytrek) in people with rare cancers that have a specific genetic change called a ROS1 gene fusion. The drug is already approved for some lung cancers, and researchers want to see if it can help shrink or control other tumor type…

This trial is testing two drugs, vemurafenib and cobimetinib, already approved for melanoma, in adults with other rare cancers that have a specific genetic change called BRAF V600 mutation. The goal is to see if the combination can shrink tumors or stop them from growing. About 3…

This study tests whether using a person's genetic information to determine the dose of the antifungal drug voriconazole leads to better drug levels in the blood compared to standard dosing. About 104 children and adults with blood cancer and a fungal infection will take part. The…

This study tests a drug called alectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change called ALK. About 30 adults, teens, and children with ALK-positive cancers will receive alectinib to see if it shrinks tumors or stops…

This study is testing a new way to manage care for 33 cancer patients who take oral chemotherapy at home. Instead of going to the hospital every month just to pick up medicine, a nurse will visit them at home twice in six months. An advanced practice nurse will coordinate everyth…

This study tests whether drugs already approved for some cancers can help people with rare cancers or common cancers that have rare genetic changes. It includes adults, teenagers, and children whose cancer has a specific mutation and who have no good standard treatment left. The …