GERM CELL TUMOR

This early-stage trial is testing a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to standard treatments. The main goals are to see if the drug is safe and to find the best dose. About 282 participants will recei…

This early-phase trial tests a four-drug combination—vorinostat plus three chemotherapy drugs—in children, teens, and young adults up to age 30 whose solid tumors or brain cancers have returned or not responded to standard treatment. The main goal is to find the safest dose of vo…

This early-phase study tests whether a new type of immunotherapy, called B7-H3 CAR T cells, can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG, DMG, or other recurrent central nervous system cancers. The…

This early-stage trial is testing a new drug called ZW251 in about 100 people with advanced solid tumors, including liver cancer (hepatocellular carcinoma), a type of lung cancer (squamous cell non-small cell lung cancer), and germ cell tumors. ZW251 is an antibody-drug conjugate…

This study tests a combination of two chemotherapy drugs, teniposide and cisplatin, in 40 people newly diagnosed with a rare brain tumor called central malignant germ cell tumor. The goal is to see how well the treatment shrinks tumors and to find biological markers that predict …

This study tests whether taking two drugs (zanzalintinib and oral etoposide) after high-dose chemotherapy can help keep relapsed germ cell tumors from growing. About 38 adults whose cancer has not been cured by standard treatments will participate. The goal is to see if this comb…

This study looks at two groups of people with germ cell tumors. For those with low-risk tumors that haven't spread, doctors will monitor them closely after surgery instead of giving chemotherapy. For standard-risk tumors that have spread, the study compares two chemotherapy drugs…

This study is for people with relapsed germ cell tumors (a type of cancer often in the testicles or ovaries) who have already had high-dose chemotherapy and a stem cell transplant. It tests whether taking a daily oral chemotherapy drug called etoposide for a while after treatment…

This study tests a new, robot-assisted technique to see if testicular cancer has spread to nearby lymph nodes. Doctors inject a green dye into the testicle, then use a robot with a special camera to find and remove the first lymph node that drains the tumor. The goal is to improv…

This study tests if a green dye called indocyanine green (ICG) can help surgeons find the first lymph nodes that cancer might spread to in children with solid tumors. Ten children under 18 will receive the dye during surgery to see if it lights up the right nodes. The goal is to …

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell tumors (including testicular cancer) who are receiving standard chemotherapy. About 35 participants will take aspirin alongside their chemo for 26 weeks. The goal…

This study follows over 1,100 children who were treated for germ cell tumors (a type of cancer). Researchers want to learn about long-term side effects like hearing loss and to analyze tumor DNA to better predict which children might have their cancer come back. Participants prov…

This study creates a registry of DNA and health information from 1,000 people with germ cell or testicular tumors, plus their relatives and unrelated volunteers. Researchers will collect data on diagnosis, family history, and risk factors to learn why some people develop these tu…

This early-stage study tests whether people with advanced solid tumors can safely follow a diet low in methionine, an amino acid found in many proteins. Researchers will measure how well participants stick to the diet, check for side effects, and track changes in blood methionine…

This study looks at 1650 people with different types of brain tumors to see if the new 2021 classification system helps doctors predict outcomes and choose treatments better than the old system. Researchers will collect information on treatments, scans, and survival over 5 years.…