GENETIC PREDISPOSITION TO DISEASE

This study looks at whether men with certain inherited gene changes (BRCA1, BRCA2, or mismatch repair genes) have a higher chance of getting prostate cancer. About 3,500 men aged 40-69 with or without these gene changes will get yearly PSA tests. The goal is to learn how often pr…

This study looks at a specific genetic variant found in about 6% of people that may raise the risk of high blood pressure, especially in men. Researchers will test 76 people with this variant and high blood pressure to see if they have a treatable condition called primary aldoste…

This early-stage study looks at whether sirolimus, an FDA-approved drug, can increase blood flow to the brain in healthy adults aged 45-65. Some participants have a genetic risk for Alzheimer's (APOE4 gene), while others do not. The goal is to understand how the drug affects brai…

This study looks at why Black people with HIV are more likely to develop kidney disease, diabetes, and heart problems. Researchers are analyzing genetic and health data from over 3,000 participants to find risk factors. The goal is to better understand these diseases and improve …