FANCONI ANEMIA

This study tests a stem cell transplant using milder chemotherapy for people with certain immune deficiencies or bone marrow failure. The goal is to see if donor cells can take over the bone marrow and restore a working immune system. About 27 participants will be enrolled, and t…

This study tests a new way to do stem cell transplants for people with Fanconi Anemia, a rare genetic condition that causes bone marrow failure. Instead of strong chemotherapy, patients get a milder prep treatment that includes an experimental antibody called JSP191. The goal is …

This study tests a special stem cell transplant that removes certain immune cells to lower the need for strong anti-rejection drugs. It is for people with inherited bone marrow failure disorders like Fanconi anemia. The goal is to help the immune system recover faster and reduce …

This study tests a stem cell transplant using lower doses of chemotherapy for people with Fanconi anemia who don't have a perfectly matched donor. The goal is to reduce serious side effects while still helping the body accept new blood-forming cells. About 70 participants will re…

This expanded access program offers a special stem cell processing technique (CD34+ selection) to patients with severe combined immune deficiency, Fanconi anemia, dyskeratosis congenita, or sickle cell disease who are receiving a stem cell transplant. The method removes certain i…

This study follows people with Fanconi anemia, a genetic condition that raises the risk of squamous cell carcinoma, especially in the mouth, throat, and genital areas. Researchers will screen 200 participants aged 12 and older (and some younger children with symptoms) every year …

This study looks at why people with certain rare bone marrow conditions (like Fanconi anemia) have a higher chance of getting cancer. Researchers will follow up to 4,000 participants and their family members over time to track cancer rates and find genetic or environmental risk f…

This study looks at anxiety related to cancer screenings in adults with Fanconi anemia, a rare condition that raises cancer risk. Researchers will observe 20 participants during their regular screening visits, noting body language, worries, and the clinic environment. The goal is…

This study collects blood, bone marrow, and other samples from people with non-cancerous blood diseases and their family members. Researchers will analyze genes to find causes of these diseases and why some people get sicker than others. The goal is to improve future diagnosis an…

This research study aims to discover new genes that may increase the risk of childhood cancer. Researchers will collect blood samples and health information from 1,500 people in families where cancer clusters. The goal is to build a registry and sample bank to help future diagnos…