EWING SARCOMA

This early-stage trial tests a new type of immunotherapy for children and young adults with solid tumors that have not responded to standard treatments. The therapy uses the patient's own immune cells (T cells) that are genetically modified to recognize and attack cancer cells ca…

This early-phase trial tests a new type of cell therapy for children and young adults with solid tumors that have come back or not responded to standard treatments. The therapy uses a patient's own immune cells, which are trained in the lab to recognize and attack multiple cancer…

This early-phase study tests a flavored, drinkable version of the chemotherapy drug irinotecan (VAL-413) combined with another drug (temozolomide) in children and young adults up to age 30 whose solid tumors have come back. The main goal is to find the safest dose and see how the…

This study tests a daily pill called cabozantinib in children and young adults (up to age 30) with rare cancers like sarcomas, Wilms tumor, and others that have come back or not responded to treatment. The drug works by blocking signals that help tumors grow and form blood vessel…

This early-stage trial tests a radioactive drug called CLR 131 in 30 children and young adults with solid tumors, lymphoma, or brain tumors that have come back or not responded to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. P…

This early-phase study tests whether adding the targeted drug regorafenib to standard chemotherapy is safe for people with newly diagnosed, widespread Ewing sarcoma. The trial enrolls about 23 patients aged 2 to 49 whose cancer has spread beyond the lungs. The goal is to find a s…

This study tests two drugs, sunitinib and temsirolimus, in 137 people with advanced rare cancers that have no cure. The goal is to see if these drugs can shrink tumors or slow their growth. While not a cure, the approach aims to better control the disease and improve survival.

This early-stage study tests whether a treatment made from a patient's own tumor-fighting immune cells (TIL) is safe for children, teenagers, and young adults with solid tumors that have come back or stopped responding to standard care. About 40 participants will receive the TIL …

This early-phase study tests a personalized cell therapy for children and young adults (up to age 26) with solid tumors that have come back or not responded to standard treatment. The therapy uses the patient's own immune cells, modified to recognize and attack a protein called B…

This study tests whether a special PET scan using a radioactive form of methionine (a natural amino acid) can help doctors see tumors in children and young adults with various cancers, including brain tumors and sarcomas. About 503 participants will be scanned to see if the metho…

This study uses a radioactive antibody called Hu3F8 to take detailed PET/CT pictures of tumors in people with melanoma, neuroblastoma, or sarcoma. The goal is to see how the antibody moves through the body and where it collects. Seven participants received the antibody and had mu…

This study looks at whether a blood test (liquid biopsy) can help predict how well children and young adults with Ewing sarcoma or osteosarcoma will do. Researchers will check for tumor DNA in the blood at diagnosis and see if it relates to cancer returning. The goal is to better…