ER+ BREAST CANCER

This study tests a new drug called JAB-2485 in adults with advanced solid tumors (like breast or lung cancer) that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors. About 102 participants will take the dr…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to a single spot where breast cancer has worsened can help keep the disease from spreading further. Participants continue their usual drug therapy while receiving SBRT. The goal is to see if this appr…

This study tests whether a special PET scan can help find the best dose of tamoxifen for people with metastatic breast cancer that has an ESR1 mutation. These mutations can make standard tamoxifen doses less effective. The study will enroll 12 participants and use FES-PET/CT imag…

This study tests a new drug called FWD1802 combined with other treatments for people with ER-positive/HER2-negative breast cancer that has spread or cannot be removed by surgery. About 196 participants will join to find safe doses and see if the combinations shrink tumors. The go…

This study tests a drug called elacestrant in 50 adults with a type of breast cancer (ER+/HER2-) who have a high risk of the cancer coming back years later. Participants must have cancer DNA in their blood but no signs of spread on scans. The goal is to see if the drug can clear …

This study is for women with a certain type of breast cancer (ER+HER2-) who have already had radiation once and now need a second lumpectomy. Researchers want to see if giving radiation again is safe and helps prevent the cancer from coming back. About 114 participants will be fo…

This study looks at whether giving hormone therapy before surgery can lower the chance of cancer cells being found at the edges of removed tissue in women with stage 2 to 3 invasive lobular breast cancer. About 176 postmenopausal women with ER+/HER2- tumors will receive neoadjuva…

This study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their…

This early-phase study tests two drugs, palbociclib and avelumab, together for people with a specific type of advanced breast cancer (AR+ triple-negative). The main goals are to find the safest doses and see if the combination can shrink tumors. About 45 participants with advance…

This study tests a decision aid for women aged 70 and older with early-stage, low-risk breast cancer. The tool helps them and their doctors discuss treatment options, aiming to reduce aggressive treatments like mastectomy or radiation when they may not be needed. About 400 partic…

This study is collecting tissue and blood samples from 500 people with breast cancer who are receiving treatment before surgery. Researchers will analyze these samples to learn why some cancers respond well to therapy while others do not. The goal is to find better ways to predic…