ENDOMETRIAL NEOPLASMS

This study tests a new drug, LY3537982, in people with advanced solid tumors that have a specific genetic change called KRAS G12C. The goal is to see if the drug is safe and shrinks tumors. About 540 adults with lung, colon, endometrial, ovarian, pancreatic, or bile duct cancers …

This early-phase study tests a new daily pill, NKT3964, that breaks down a protein called CDK2 to slow cancer growth. It is for adults with advanced solid tumors (like ovarian, endometrial, breast, gastric, or lung cancer) that have not responded to standard treatments. The study…

This study is for people with endometrial cancer that has come back or spread to a few other spots. It tests a new drug called cadonilimab given together with chemotherapy and radiation. The goal is to see if this combination can shrink tumors and help people live longer without …

This study tests atezolizumab, a drug already approved for some cancers, in people with rare cancers that have high tumor mutational burden (TMB), high microsatellite instability (MSI), or a specific DNA repair defect (CMMRD). About 30 adults, teens, and children will receive the…

This study tests whether the immunotherapy drug dostarlimab, given alone or with bevacizumab, works better than standard chemotherapy for people with recurrent gynecological clear cell carcinoma (a rare cancer of the ovary, uterus, cervix, vagina, or vulva). About 198 participant…

This early-stage study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced breast, colorectal, prostate, or endometrial cancer that has spread. The goal is to find a safe dose and see if it s…

This early-phase study tests a new drug called DM002 in about 160 people with advanced solid tumors (ovarian, prostate, endometrial, colorectal, or other solid cancers). The study has two parts: first, finding a safe dose by giving small groups gradually higher doses; second, giv…

This study tests a new drug called LY4175408 in people with advanced lung, endometrial, or breast cancer that has spread. The drug is designed to target and kill cancer cells while sparing healthy ones. The goal is to check safety, how the drug moves through the body, and whether…

This study tests a new drug called LY4170156 in people with advanced solid tumors, such as ovarian, lung, and breast cancers. The drug is designed to target and kill cancer cells while sparing healthy ones. The trial has two parts: first to find the safest dose, then to see how w…

This study looks at whether using a uterine manipulator (a tool to move the uterus) during minimally invasive hysterectomy for endometrial cancer increases the risk of cancer coming back. About 1,030 women with early-stage endometrial cancer will be randomly assigned to have surg…

This study is a large registry that will follow about 2,000 people in Germany with advanced ovarian or endometrial cancer. Researchers will collect information on treatments, side effects, and quality of life over time. The goal is to understand what really happens in everyday me…