Endocrine system diseases

This study tests whether a drug called AMX0035 can improve how the body responds to insulin in adults with type 1 diabetes. Participants take either AMX0035 or a placebo daily for 24 weeks. Researchers measure insulin sensitivity using a glucose clamp test and track blood sugar c…

This study tests a once-daily pill called orforglipron in adults with type 2 diabetes who plan to fast during Ramadan. The goal is to see if the drug helps control blood sugar and weight without causing harm. About 130 participants will take the pill for up to 48 weeks, with clin…

This phase 3 trial tests higher daily doses (over 30 mcg) of palopegteriparatide (Yorvipath) in 36 adults with chronic hypoparathyroidism. Participants already on the drug will have their dose adjusted to find the best level for controlling calcium without needing extra vitamin D…

This study tests whether an online training and support platform can help adults with type 1 diabetes better manage their blood sugar and well-being. About 322 participants across Canada will use the platform for 12 months, either as part of their usual clinic care or on their ow…

This study tests whether an online training and peer support platform (Support-t) helps teens with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either use the platform plus usual care or just usual care. The main goal is…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This study looks at whether newer automated insulin delivery systems help people with type 1 diabetes have healthier eating behaviors. Researchers will survey over 100 youth and adults across Canada about their eating habits and blood sugar control. The goal is to understand if t…