EMPHYSEMA

This trial tests a device called the Implantable Artificial Bronchus (IAB) for people with COPD or emphysema. The device is placed in the lungs to reduce over-inflation and improve airflow. About 20 adults will be enrolled to check if the device is safe enough for a larger study.…

This study is testing a new drug called SAR447537 in adults with Alpha-1 antitrypsin deficiency (AATD) emphysema, a genetic condition that damages the lungs. The goal is to see if the drug is safe and helps control the disease over the long term. About 185 participants will recei…

This study tests whether the antibiotic doxycycline can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers aged 30 and older with HIV are taking doxycycline for 72 weeks. Researchers measure lung function, walking distance, and check fo…

This study looks at why some smokers develop chronic obstructive pulmonary disease (COPD) while others don't. Researchers are studying over 10,000 smokers and non-smokers to find genetic factors that may increase COPD risk. The goal is to better understand the disease, not to tes…

This study looks at how the health of blood vessels and genetics may be linked to early signs of COPD and emphysema. Over 4,300 adults from a larger heart study took part. Researchers measured lung function and used CT scans to check for lung damage, aiming to understand the role…

This study follows nearly 3,000 people with COPD (a chronic lung disease) over several years to better understand how the disease progresses. Researchers measure lung function, mucus, and CT scans, and also look at how things like air pollution and home environment affect health.…