Disorders of consciousness
Clinical trials for Disorders of consciousness explained in plain language.
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Can a 'temporal interference' electric field nudge the brain back toward awareness?
Disease control CompletedThis trial tests whether a non-invasive brain stimulation technique called temporally interfering (TI) electrical stimulation can help people with disorders of consciousness, such as a minimally conscious state or unresponsive wakefulness syndrome. Participants receive either rea…
Matched conditions: DISORDERS OF CONSCIOUSNESS
Sponsor: Zhejiang Provincial People's Hospital • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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Gentle touch may reveal hidden awareness in unresponsive patients
Diagnosis CompletedResearchers are studying how the brain and body react to different types of touch in people with disorders of consciousness. Eight adults with these conditions receive pleasant, neutral, and unpleasant touches on their arms and hands while brain activity is recorded using EEG and…
Matched conditions: DISORDERS OF CONSCIOUSNESS
Sponsor: Anna Estraneo • Aim: Diagnosis
Last updated Sep 13, 2026 00:00 UTC
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Can emotional brain waves wake the unresponsive?
Symptom relief CompletedThis study tested a new device called Intensive Neurowave Emotional Stimulation (INES) in 40 people with disorders of consciousness after severe brain injury. The experimental group received multisensory stimulation with emotionally meaningful audio-visual content, while the cont…
Matched conditions: DISORDERS OF CONSCIOUSNESS
Sponsor: IRCCS Centro Neurolesi Bonino Pulejo • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Can a tickle reveal hidden awareness? scientists test brain responses in unresponsive patients
Knowledge-focused CompletedResearchers are investigating whether tickling can briefly change how responsive patients with disorders of consciousness are, compared with plain touch. The study includes 16 adults who have been in a disorder of consciousness for at least 28 days after a severe brain injury. Pa…
Matched conditions: DISORDERS OF CONSCIOUSNESS
Sponsor: Anna Estraneo • Aim: Knowledge-focused
Last updated Sep 13, 2026 00:00 UTC
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Blink of an eye: new study uses eye movements to assess brain injury patients
Knowledge-focused CompletedThis study looks at whether spontaneous eye blinking can help doctors understand the level of consciousness and attention in people with severe acquired brain injury. Researchers will record eye blinks using simple sensors while patients rest or listen to sounds. The goal is to d…
Matched conditions: DISORDERS OF CONSCIOUSNESS
Sponsor: Alfonso Magliacano • Aim: Knowledge-focused
Last updated Jul 12, 2026 00:00 UTC
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Sound waves could unlock the minds of Brain-Injured patients
Knowledge-focused CompletedThis study tests whether ultrasound can help doctors better understand and treat people with disorders of consciousness, like coma or a minimally conscious state, after severe brain injury. Researchers will use ultrasound to look at brain structure and function, and also try low-…
Matched conditions: DISORDERS OF CONSCIOUSNESS
Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC
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Robots help brain injury patients take first steps in new feasibility trial
Knowledge-focused CompletedThis study tested two types of robot-assisted training for people recovering from a severe brain injury. Ten participants were randomly assigned to either five days of robot-assisted walking training or five days of robot-assisted stepping training, then switched to the other. Th…
Matched conditions: DISORDERS OF CONSCIOUSNESS
Sponsor: Christina Kruuse • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC