CYSTIC FIBROSIS (CF)

This study tests a new medicine called ANG003 for people with cystic fibrosis who have trouble digesting food (exocrine pancreatic insufficiency). The medicine is a type of enzyme replacement that helps break down fats, proteins, and carbs. Researchers want to see if ANG003 is sa…

This study tests a wellness program designed for adults with cystic fibrosis who struggle with fatigue and poor sleep. The program includes eight coaching sessions covering topics like balancing activity and rest, improving sleep, and managing stress. Researchers will enroll 80 p…

This study tests whether a self-help version of Acceptance and Commitment Therapy (ACT), delivered via smartphone, can reduce anxiety and depression in adults with cystic fibrosis. About 60 participants will use the toolkit and report their symptoms. The goal is to improve mental…

This study tests a smartphone program called NUDGE that acts like a health coach for teens and young adults (ages 13-25) with cystic fibrosis. Participants set activity goals, track progress, and get feedback through the app. The goal is to see if the app helps them stay active a…

This study looks at whether a Mediterranean diet can improve gut health in children with cystic fibrosis. Twenty kids aged 3 and older will follow this diet for 6 months. Researchers will check changes in gut bacteria and inflammation markers. The goal is to offer better diet adv…

This study looks at why people with cystic fibrosis often develop kidney disease. Researchers will test blood and urine samples for early signs of kidney damage, comparing CF patients with and without frequent hospital stays, as well as people without CF. The goal is to find bett…

This study looks at how linaclotide, a drug for constipation, affects fluid in the gut. Researchers will use MRI scans to see where the drug works in the small and large intestines. The goal is to learn more about its effects, which could help design future studies for conditions…

This study looks at how cystic fibrosis affects children's breathing, muscle strength, bladder control, and daily life compared to healthy kids. Researchers will measure grip strength, lung function, and other health markers in 50 children aged 6-18. The goal is to identify probl…

This study is not testing a treatment. Instead, it checks how accurate and repeatable lab tests and research techniques are for studying conditions like obesity, diabetes, heart disease, and osteoporosis. Up to 100 healthy volunteers or people with these conditions will provide s…

This study tests whether wearable sensors and artificial intelligence can detect changes in the body during a chest infection in adults with cystic fibrosis or bronchiectasis. Fifty participants will wear sensors while receiving intravenous antibiotics for about two weeks. The go…

This study watches 200 people with cystic fibrosis to learn how their bodies react to standard treatments for severe lung infections. Researchers track symptoms, lung function, and collect samples to understand why some people recover better than others. The goal is to use this k…

This study follows 300 people with cystic fibrosis for one year to learn what triggers sudden worsening of symptoms, called exacerbations. Participants provide regular health data and samples, and some will also have extra clinic visits and home monitoring. The goal is to find ea…

This study looks at adults with cystic fibrosis who are taking a drug combination called ETI (Elexacaftor-Tezacaftor-Ivacaftor). The goal is to find out how many of them still have trouble breathing during a 6-minute walk test. Researchers will also check breathing during a harde…

This early-stage study tests whether two new drug combinations for cystic fibrosis are safe in healthy adults aged 18 to 55. Participants will receive either the study drugs or a placebo, and researchers will monitor for side effects and how the drugs move through the body. The g…