CYSTIC FIBROSIS (CF)

This study tests a new pancreatic enzyme replacement called ANG003 for people with cystic fibrosis who have trouble digesting food. About 113 participants will take either ANG003 or the standard enzyme Creon to see if it is safe and works as well. The goal is to help the body abs…

This study tests a wellness program for adults with cystic fibrosis who struggle with fatigue and poor sleep. About 80 participants will either join the program or continue their usual care. The goal is to see if the program helps improve energy, sleep quality, and daily activity…

This study tests a smartphone program called NUDGE that acts like a health coach for teens and young adults (ages 13-25) with cystic fibrosis. Participants set activity goals, track progress, and get feedback through the app. The goal is to see if the app helps them stay active a…

This study tests whether a self-help version of Acceptance and Commitment Therapy (ACT), delivered via smartphone, can reduce anxiety and depression in adults with cystic fibrosis (CF). 60 participants with CF and mild mood symptoms will use the toolkit and be monitored for chang…

This study watches 200 people with cystic fibrosis to learn how their bodies react to standard treatments for severe lung infections. Researchers track symptoms, lung function, and collect samples to understand why some people recover better than others. The goal is to use this k…

This study compares children and teens (ages 6-18) with cystic fibrosis to healthy kids of the same age. Researchers will measure hand grip strength, breathing difficulty, lung function, and quality of life to see how CF affects daily living. The goal is to better understand the …

This study looks at how a Mediterranean diet affects the gut health of 20 children with cystic fibrosis (CF) ages 3 and older. Participants will follow the diet for 6 months, and researchers will measure changes in gut bacteria and inflammation. The goal is to provide clearer die…

This study aims to make sure that lab tests, equipment, and procedures used in research on obesity, diabetes, heart disease, and bone/muscle conditions are accurate and give the same results each time. About 100 healthy volunteers and people with these conditions will provide sam…

This study tests whether wearable sensors and artificial intelligence can detect changes in the body, like heart rate and breathing rate, during a chest infection. It involves 50 adults with cystic fibrosis or bronchiectasis who are starting intravenous antibiotics. The goal is t…

This study follows 300 people with cystic fibrosis for one year to learn what triggers sudden worsening of symptoms, called exacerbations. Participants provide regular health data and samples, and some will also have extra clinic visits and home monitoring. The goal is to find ea…

This study uses MRI scans to see exactly where the drug linaclotide works in the gut. Linaclotide is currently used for constipation, but researchers want to know if it could help people with cystic fibrosis, who have trouble moving fluid through their intestines. 26 healthy adul…

This study looks at adults with cystic fibrosis who are taking a drug combination called ETI (Elexacaftor-Tezacaftor-Ivacaftor). The goal is to find out how many of them still have trouble breathing during a 6-minute walk test. Researchers will also check breathing during a harde…

This study aims to understand why people with cystic fibrosis (CF) often develop kidney disease. Researchers will collect blood and urine samples from 260 CF patients (both in and out of the hospital) and compare them to samples from people without CF. The goal is to find early w…

This early-stage study tests whether two new drug combinations for cystic fibrosis are safe in healthy adults aged 18 to 55. Participants will receive either the study drugs or a placebo, and researchers will monitor for side effects and how the drugs move through the body. The g…