CRITICAL LIMB ISCHEMIA

This early-stage study tested a new medicine called VM202 in 12 people with critical limb ischemia, a severe form of leg artery disease that causes pain and sores. The goal was to see if the injections are safe and tolerable. Participants had not gotten better with standard treat…

This study tested a temporary stent designed to open blocked arteries below the knee in 130 people with severe leg artery disease. The goal was to improve blood flow and prevent major complications like amputation or death within 30 days. The stent is removed after the procedure,…

This study tested a device that creates a new connection between a vein and an artery below the knee to restore blood flow in people with critical limb ischemia, a severe condition where blood flow is blocked and standard treatments have failed. The goal was to prevent amputation…

This study tested a device that creates a small connection between a vein and artery below the knee to reroute blood flow in people with critical limb ischemia, a severe blockage that puts the leg at risk of amputation. 34 participants who had no other treatment options were enro…

This study looked at 40 people with severe leg artery blockages (critical limb ischemia) to see if opening one or multiple arteries with angioplasty works better. The goal was to save the leg from major amputation and help wounds heal. Researchers compared outcomes between patien…

This study tested a gene therapy called VM202 (Engensis) in 52 people with critical limb ischemia, a severe blockage of leg arteries causing pain and risk of amputation. Participants received injections into the calf muscle to see if it safely improves blood flow and reduces pain…

This study looked at how well simple bedside tests (like using a Doppler device or checking blood pressure in the ankle and toe) can detect poor leg circulation in people with diabetes. Poor circulation is a major cause of leg amputations in diabetes. The study involved 604 adult…