Coronary microvascular dysfunction

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study tests a simple balloon inflation technique to modify blood clots during emergency heart artery opening. 100 heart attack patients will either get the balloon procedure or standard care. The goal is to see if this reduces damage to the heart muscle and improves recovery…

This study tests a new wireless pressure microcatheter to diagnose coronary microvascular dysfunction (CMD) in people with chest pain but no major artery blockages. Researchers will compare the device's measurements to heart MRI scans in 114 participants. If accurate, it could of…

This study tests whether the drug vericiguat can improve blood flow in the tiny vessels of the heart and reduce chest pain. About 94 adults aged 40-75 with stable chest pain but no major blockages will take the drug or a placebo. The main goal is to see if heart blood flow improv…

This study looks at how small vessel disease—narrowing of the tiny arteries in the heart—might contribute to a condition called pre-heart failure with preserved ejection fraction (pre-HFpEF), where the heart muscle doesn't relax properly despite pumping normally. Researchers will…

This study looks at 150 adults who had a heart attack but whose main heart arteries were not blocked. Researchers will use special imaging and pressure tests to check for problems in the tiny blood vessels of the heart. The goal is to see if these microvascular issues lead to wor…

This observational study at Imperial College London will enroll 70 people undergoing heart catheterization to understand why some patients tolerate ventricular tachycardia (VT) better than others. Researchers will measure blood pressure and blood flow in the heart during simulate…

This study uses a special heart MRI to see if a device called a coronary sinus reducer can improve blood flow in patients with heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (small vessel disease). The device is implanted to reroute …

This study looks at how mental stress impacts the small blood vessels of the heart in postmenopausal women with coronary microvascular dysfunction (CMD). Researchers will measure heart activity, stress responses, and daily symptoms in 150 women using imaging, questionnaires, and …