Could a new pill unlock better blood flow for stubborn chest pain?
NCT ID NCT06239974
First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times
Summary
This study tests whether the drug vericiguat can improve blood flow in the tiny vessels of the heart and reduce chest pain. About 94 adults aged 40-75 with stable chest pain but no major blockages will take the drug or a placebo. The main goal is to see if heart blood flow improves on special scans.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 94 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Sep 2024
- Expected to finish
-
Aug 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
40 to 75 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Stable recurrent chest pain. 2. 40 to 75 years old. 3. Have coronary computed tomography (CT) angiogram or catheter coronary angiogram within 6 months showing non-obstructive coronary artery disease (\<50% coronary artery stenosis or fractional flow reserve \>0.8). 4. Stress CMR MPR \<2.19 12 or Stress MBF \<2.19ml/g/min 13. 5. Female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP),or is a WOCBP and agrees to follow contraceptive guidance during the study intervention period and for at least 1 month after the last dose of study intervention. Exclusion Criteria: 1. Systolic blood pressure \<100 mm Hg. 2. Concurrent use of soluble guanylate cyclase stimulators (eg. Riociguat), or phosphodiesterase type 5 inhibitors (eg. vardenafil, tadalafil, and sildenafil). 3. Has known allergy or sensitivity to any soluble guanylate cyclase stimulator. 4. On long-acting nitrates (eg. isosorbide mononitrate) 5. Known cardiomyopathy, complex congenital heart disease, endocarditis or pericarditis. 6. Has acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction (NSTEMI), or ST elevation myocardial infarction (STEMI)) or coronary revascularization (coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI)) within 60 days prior to randomisation, or indication for coronary revascularization at time of randomisation. 7. Has symptomatic carotid stenosis, transient ischemic attack (TIA) or stroke within 60 days prior to randomisation. 8. Estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m2 9. Malignancy or other non-cardiac condition limiting life expectancy to \<3 years. 10. Patient's with implanted devices which are not MRI compatible.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Chest pain are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
The University of Hong Kong
RECRUITINGHong Kong, Hong Kong
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Magnetic heart signals could help ER doctors spot hidden heart risk
- Can a Plant-Based diet restore blood flow in the Heart's small vessels?
- A quick scoring tool may help emergency call centers spot the most dangerous chest pain cases
- Can tiny heart vessel damage predict heart failure?
- Can an AI chatbot help ER doctors spot serious chest pain faster?
- Smartwatch ECG: a new frontier in heart attack detection?