Colonic neoplasms

This phase I/II platform trial tests several drug combinations, including evorpacept, trastuzumab deruxtecan, zanidatamab, tucatinib, and TTX-MC138, in people with advanced solid tumors, especially metastatic breast cancer. The goal is to find safe and promising regimens that cou…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This study looks at whether keyhole surgery (laparoscopic) or traditional open surgery leads to better long-term results for colon cancer patients who have extra belly fat. About 664 adults aged 18 to 75 with colon cancer and a high Body Roundness Index will take part. The main g…

This phase 3 trial tests the immunotherapy drug dostarlimab against standard chemotherapy in 892 people with a specific type of colon cancer (dMMR/MSI-H) that has not spread. The goal is to see if dostarlimab alone can prevent cancer from coming back or causing death. Participant…

Colon cancer is common but preventable if caught early. While colonoscopy is the best screening tool, many people can't get one due to cost or time. This study collects stool and blood samples from 1,200 adults to find proteins that signal colon polyps or cancer. The goal is to d…

This study tests ways to improve colorectal cancer screening in Appalachia by mailing fecal immunochemical test (FIT) kits to 500 people who are due for screening. Some participants get an enhanced kit with a video brochure and gloves, plus phone or text reminders. The goal is to…

This study looks at whether aerobic exercise can help people with stage II or III colon cancer tolerate more of their planned chemotherapy. About 219 participants who have had surgery and are about to start chemo will be randomly assigned to an exercise program or a control group…

This trial compares two methods of examining colon cancer tissue after surgery: the European method, which relies solely on pathologists, and the Japanese method, which involves surgeons in finding lymph nodes. The goal is to see if the Japanese method is as accurate as the Europ…

This study looks back at medical records of 2000 adults who had endoscopic removal of cancerous or precancerous growths in the esophagus, stomach, duodenum, colon, or rectum. The goal is to compare different removal methods to see which works best and has the fewest complications…