CLINICAL STAGE IV GASTRIC CANCER AJCC V8

This Phase III trial is testing whether adding radiotherapy to standard chemotherapy helps people with HER2-negative esophageal or gastric cancer that has spread to a few other spots in the body. About 314 participants are receiving either chemotherapy alone or chemotherapy plus …

This early-phase trial tests an experimental drug called BAY 1895344 combined with standard chemotherapy (cisplatin, with or without gemcitabine) in people with advanced solid tumors, especially urothelial cancer. The goal is to find the best dose and see how safe the combination…

This early-phase trial tests the safety and best dose of the chemotherapy drug paclitaxel when given directly into the abdomen (intraperitoneal) for people with advanced stomach or gastroesophageal junction cancer that has spread to the lining of the abdomen. About 27 participant…

This early-phase trial is testing whether combining the targeted drug trastuzumab deruxtecan (DS-8201a) with an experimental pill called ceralasertib can safely treat advanced solid tumors that have a HER2 mutation. The study has two parts: first, finding the safest dose in 51 pa…

This early-phase trial tests two drugs together—sonidegib and pembrolizumab—in 36 adults with advanced solid tumors that have spread. Sonidegib blocks a growth signal in cancer cells, while pembrolizumab helps the immune system attack the tumor. The main goals are to find the saf…

This study tested a combination of two drugs, berzosertib and irinotecan, in 17 people with advanced stomach or gastroesophageal junction cancer that had a specific genetic change (TP53 mutation) and was no longer responding to other treatments. The goal was to see if the combina…

This study tests whether using telemedicine and remote monitoring can help people with advanced digestive cancers manage chemotherapy side effects at home, reducing the need for emergency room visits and hospital stays. About 750 patients and their caregivers will receive enhance…

This study collects tissue and blood samples from 1,600 people with various advanced cancers, along with their medical information, over the course of their treatment. Researchers will store these samples and data in a biobank for current and future studies. The goal is to better…