CHRONIC LIMB-THREATENING ISCHEMIA
Clinical trials for CHRONIC LIMB-THREATENING ISCHEMIA explained in plain language.
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New scaffold device aims to save limbs in High-Risk patients
Disease control Not yet recruitingThis study tests a temporary scaffold system to open blocked leg arteries in people with chronic limb-threatening ischemia (CLTI), a severe form of peripheral artery disease. The device is removed after treatment, and a drug-coated balloon is used to keep the artery open. The stu…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Medical University of Graz • Aim: Disease control
Last updated May 26, 2026 02:53 UTC
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Old gout drug may save legs in severe artery disease
Disease control Not yet recruitingThis study tests whether a low dose of colchicine, a common anti-inflammatory drug, can help people with severe leg artery disease (chronic limb-threatening ischemia) avoid amputation or death. About 200 adults who recently had a procedure to restore blood flow in their leg will …
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Phase: PHASE3 • Sponsor: Shin Kong Wu Ho-Su Memorial Hospital • Aim: Disease control
Last updated May 26, 2026 02:52 UTC
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Dissolving scaffolds could save legs from amputation
Disease control Not yet recruitingThis study will test a new treatment for people with severe leg artery disease that causes pain and wounds. The treatment uses a temporary scaffold that releases medicine to keep the artery open and then dissolves over time. Researchers will follow 400 patients across Europe to s…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Cardiovascular and Interventional Radiological Society of Europe • Aim: Disease control
Last updated May 22, 2026 14:03 UTC
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New Wound-Focused approach may prevent amputations in leg artery disease
Disease control Not yet recruitingThis study tests whether a new approach called 'woundsome revascularization' can save more legs in people with severe artery disease that threatens the limb. It involves 50 adults with chronic limb-threatening ischemia who need a procedure to reopen blocked arteries below the kne…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Phase: NA • Sponsor: Assiut University • Aim: Disease control
Last updated May 22, 2026 13:53 UTC
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Spinning tool could save limbs: new study targets hardened arteries
Disease control Not yet recruitingThis study will follow 250 people with severe leg artery disease (chronic limb-threatening ischemia) to see how well a procedure called orbital atherectomy works in real life. The procedure uses a tiny spinning device to grind away hard calcium inside the artery, making it easier…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Cardiovascular and Interventional Radiological Society of Europe • Aim: Disease control
Last updated May 20, 2026 11:54 UTC
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Blood test may reveal new way to treat blocked leg arteries
Knowledge-focused Not yet recruitingThis observational study looks at whether a receptor called GLP1R on blood cells differs between people with mild versus severe peripheral artery disease. Researchers will collect one extra blood sample from 50 adults during routine care to measure this receptor and related infla…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated May 18, 2026 12:01 UTC