Chronic limb-threatening ischemia
Clinical trials for Chronic limb-threatening ischemia explained in plain language.
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Gene therapy shots aim to save legs from amputation in diabetes
Disease control Not yet recruitingResearchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Phase 4 • Sponsor: First Affiliated Hospital of Wenzhou Medical University • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Can a sound wave camera inside arteries save more legs?
Disease control Not yet recruitingThis study compares two ways to guide a minimally invasive procedure that opens blocked arteries below the knee in people with chronic limb-threatening ischemia, a severe form of peripheral artery disease. One group receives standard X-ray guidance (angiography) alone; the other …
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Shin Kong Wu Ho-Su Memorial Hospital • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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Dissolvable scaffolds could save legs from amputation in major new trial
Disease control Not yet recruitingThis Europe-wide study will follow 400 people with severe leg artery disease (chronic limb-threatening ischemia) to see if a new dissolvable, drug-coated scaffold can keep leg arteries open better than standard treatments. The scaffold releases medication to prevent re-blockage a…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Cardiovascular and Interventional Radiological Society of Europe • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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New study tests orbital atherectomy to save limbs in patients with severe leg artery disease
Disease control Not yet recruitingThis study will follow 250 people with chronic limb-threatening ischemia (CLTI) across Europe to see how well orbital atherectomy works in real life. The procedure uses a tiny spinning tool to gently remove hard calcium from leg arteries, making it easier for balloons or stents t…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Cardiovascular and Interventional Radiological Society of Europe • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
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New 'Woundsome' technique aims to save legs from amputation
Disease control Not yet recruitingThis study tests a procedure called woundsome revascularization in 50 people with chronic limb-threatening ischemia (CLTI), the most severe form of peripheral artery disease. Doctors use balloon angioplasty to open blocked arteries that supply blood directly to the wound area. Th…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Assiut University • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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A window into living tissue: new sensor may spot dangerous oxygen drops during surgery
Knowledge-focused Not yet recruitingThis observational study tests a spectroscopic sensor that measures oxygen levels in muscle tissue during vascular surgery. It aims to see if the sensor can detect changes in oxygenation when blood flow is temporarily blocked and then restored. The study involves 30 adults underg…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: Spectrocor • Aim: Knowledge-focused
Last updated Aug 28, 2026 00:00 UTC
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Could a diabetes drug help treat blocked leg arteries? new study investigates
Knowledge-focused Not yet recruitingThis observational study will examine whether a protein called the GLP-1 receptor is more active in patients with severe leg artery disease compared to those with milder symptoms. Researchers will take one extra blood sample from 50 adults with peripheral artery disease to measur…
Matched conditions: CHRONIC LIMB-THREATENING ISCHEMIA
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC