CHRONIC LIMB-THREATENING ISCHEMIA

This study is testing a special device that uses sound waves (lithotripsy) to break up hard calcium deposits in leg arteries of people with chronic limb-threatening ischemia (CLTI). The goal is to see if this treatment helps wounds heal and prevents the need for amputation. Resea…

This study tests a new device called the MAGNITUDE BRS System, a temporary scaffold that slowly releases medicine to keep leg arteries open. It is for people with severe leg artery disease that threatens the limb. About 300 participants will be randomly assigned to receive this s…

This study tests a new medicine called APAC that helps prevent blood clots in people with blocked leg arteries. It includes up to 42 adults aged 45-85 with severe disease, some of whom will have a procedure to restore blood flow. The goal is to see if APAC is safe and find the be…

This study is testing a special balloon coated with medicine to open blocked arteries below the knee in people with severe leg artery disease (chronic limb-threatening ischemia). The goal is to improve blood flow, avoid amputation, and keep arteries open longer. About 1000 partic…

This study tests a new procedure that uses a vein to reroute blood flow in people with late-stage chronic limb-threatening ischemia, a severe form of peripheral artery disease that can lead to amputation. About 100 participants will receive the LimFlow System treatment. The main …

This study tests a new surgery called transverse tibial bone transport for people with severe leg artery disease who have no other treatment options. The goal is to improve blood flow, heal wounds, and prevent major amputation. Ten participants will be followed to see if the proc…

This study compares two methods to guide balloon treatment for blocked leg arteries in people with chronic limb-threatening ischemia (severe wounds). One method uses standard X-ray images; the other adds a pressure wire to measure blood flow. The goal is to see which approach bet…

This study tests three types of leg exercises (leg press, vibration, or mixed) to see which best improves blood flow and walking ability in older adults with poor circulation or chronic wounds. 425 participants will exercise 3 times a week for 12 weeks. The goal is to find a safe…

This study looks at 450 people with severe leg artery disease who need bypass surgery. Doctors will use special tools during the operation to measure blood flow and take ultrasound images. The goal is to see if these checks can predict whether the bypass will stay open and work w…

This study aims to understand how inflammation, calcium buildup, and blood clots behave in the arteries of people with peripheral artery disease (PAD). Researchers will use special PET scans to take detailed pictures of these processes in the legs and other parts of the body. Abo…