CHRONIC KIDNEY DISEASE (STAGES 4 AND 5)

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

This study tests whether a simple home exercise program—walking and strength training—can prevent memory and thinking problems from getting worse in people with advanced chronic kidney disease (stages 4 and 5). About 124 participants will either follow the exercise plan or receiv…

This study tests whether having people with advanced chronic kidney disease report their symptoms each month through an app—and sharing those results with their kidney doctor—can improve their quality of life. About 70 adults with stage 4 or 5 kidney disease will either use the a…

This study tests whether adding a breathing feedback device to simple breathing exercises can reduce symptoms and improve quality of life in adults with advanced chronic kidney disease. Twenty-four participants will practice the exercises three times daily for six weeks. Research…

This study tests how the diabetes drug canagliflozin (Invokana) spreads through the body in 10 dialysis patients with severe kidney disease. Using PET scans, researchers want to see if the drug reaches tissues like the heart and blood vessels, not just the kidneys. The goal is to…

This observational study will measure thyroid hormone levels in stored blood and urine samples from 51 people with severe chronic kidney disease (stages 4 and 5). Researchers aim to understand how these hormones differ in patients with and without polycystic kidney disease. The s…

APT-KIDNEY is a large, flexible clinical trial platform designed to test multiple treatments for advanced kidney disease more efficiently. It will enroll up to 5,000 adults with severe kidney problems or those on dialysis. By using electronic health records and adaptive methods, …

This study will survey 400 adults with moderate to severe chronic kidney disease in Réunion Island to find out how many use herbal medicines and whether those herbs affect how fast their kidney disease gets worse over one year. Participants will fill out questionnaires about thei…

This study looks at whether a new way of measuring kidney function (using an injection of iohexol and finger-prick blood tests) can better predict when people with advanced kidney disease will start feeling sick from kidney failure. It also checks if this method can accurately me…