Chronic heart failure with reduced ejection fraction

This trial tests a small device called the C-MIC System, which is implanted under the skin and delivers a constant low-level electrical current to the heart. The goal is to see if this microcurrent can improve heart pumping ability, exercise capacity, and quality of life in peopl…

This study looks at whether adding a small amount of salt (3 grams daily) to the diet can help people with chronic heart failure who have low blood sodium levels. Researchers will compare salt pills to a placebo in 30 adults over three months. The goal is to see if salt improves …

This study tests whether adding HeartLogic diagnostic alerts to usual care can reduce hospitalizations and improve quality of life for people with chronic heart failure and low ejection fraction. About 135 adults with a prior heart failure event will be enrolled. The approach use…

This study looks at whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard heart failure medications can help people with chronic heart failure walk farther and improve heart function. About 150 adults with reduced heart pumping abil…

This Phase 3 trial will test whether glimepiride, a standard diabetes pill, can reduce the risk of heart-related death, heart transplant, or worsening heart failure in people with type 2 diabetes and chronic heart failure. About 1,484 participants will receive either glimepiride …

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study compares two supervised exercise programs—neuromuscular training (focusing on balance and coordination) and resistance training (using weights and bands)—in 40 adults with chronic heart failure. Over 10 weeks, researchers will measure how far participants can walk, the…